Advanced Biomedical Research
A rare case of humerus synovial sarcoma originated from bone tissue: Case report
Authors
Department of Orthopedic Surgery, Isfahan University of Medical Sciences, Isfahan, Iran
Abstract
Synovial sarcoma (SS) is a malignant mesenchymal neoplasm that is relatively common in the distal extremities. Primary SS of bone is an extremely rare finding. Here in this report, we present a 44-year-old male patient referred with bone and later bone fracture that was finally diagnosed with primary SS of thumerus. So far, 13 documented cases of primary SS of the bone have been reported. The current case is the second known case of primary SS of humerus. Our case was treated with both neoadjuvant and adjuvant chemotherapies associated with surgical tumor removal and prosthesis implantation. Follow-up of the case demonstrated significant remission but with late metastasis and subsequent advanced chemotherapy regimens.
Keywords
| 1. |
Stacchiotti S, Van Tine BA. Synovial sarcoma: Current concepts and future perspectives. J Clin Oncol 2018;36:180-7.  |
| 2. |
Sbaraglia M, Righi A, Gambarotti M, Vanel D, Picci P, Dei Tos AP. Soft tissue tumors rarely presenting primary in bone; diagnostic pitfalls. Surg Pathol Clin 2017;10:705-30. |
| 3. |
El Beaino M, Araujo DM, Lazar AJ, Lin PP. Synovial sarcoma: Advances in diagnosis and treatment identification of new biologic targets to improve multimodal therapy. Ann Surg Oncol 2017;24:2145-54. |
| 4. |
McHugh KE, Reith JD, Mesko NW, Kilpatrick SE. Primary intraosseous synovial sarcoma with molecular confirmation: Expanding and clarifying the spectrum of this rare neoplasm. Case Rep Pathol 2020;2020. |
| 5. |
Fujibuchi T, Miyawaki J, Kidani T, Imai H, Kiyomatsu H, Kitazawa R, et al. Intraosseous synovial sarcoma of the distal ulna: A case report and review of the literature. BMC Cancer 2019;19:1-7. |
| 6. |
Horvai A, Dashti NK, Rubin BP, Kilpatrick SE, Rudzinski ER, Lopez-Terrada D, et al. Genetic and molecular reappraisal of spindle cell adamantinoma of bone reveals a small subset of misclassified intraosseous synovial sarcoma. Mod Pathol 2019;32:231-41. |
| 7. |
Verbeke SL, Fletcher CD, Alberghini M, Daugaard S, Flanagan AM, Parratt T, et al. A reappraisal of hemangiopericytoma of bone; analysis of cases reclassified as synovial sarcoma and solitary fibrous tumor of bone. Am J Sur Pathol 2010;34:777-83. |
| 8. |
O'Donnell P, Diss T, Whelan J, Flanagan A. Synovial sarcoma with radiological appearances of primitive neuroectodermal tumour/Ewing sarcoma: Differentiation by molecular genetic studies. Skeletal Radiol 2006;35:233-9. |
| 9. |
Jung SC, Choi J-A, Chung J-H, Oh JH, Lee JW, Kang HS. Synovial sarcoma of primary bone origin: A rare case in a rare site with atypical features. Skeletal Radiol 2007;36:67-71. |
| 10. |
Beck SE, Nielsen GP, Raskin KA, Schwab JH. Intraosseous synovial sarcoma of the proximal tibia. Int J Surg Oncol 2011;2011.
|
)