Nocardial brain abscess in a patient with pulmonary alveolar proteinosis


1 Department of Infectious Diseases, Acquired Immunodeficiency Research Center, Isfahan, Iran

2 Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

3 Department of Infectious Diseases, Nosocomial Infection Research Center, Isfahan University of Medical Sciences, Isfahan, Iran


Brain abscesses caused by Nocardiaare rare but have a very high mortality and specific requirements of antibiotic treatment. Nocardial brain abscesses are mainly found in patients with predisposing conditions such as pulmonary alveolar proteinosis (PAP), a disease associated with chronic exposure to silica dust. We present a case of multiple nocardial brain abscesses in a man with PAP probably due to long-term occupational exposure to silica dust. Conclusively, in patients presenting brain abscesses and a history of chronic exposure to silica dust, PAP and opportunistic nocardial infection should always be considered as possible diagnoses.


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