Osseous Metaplasia in Rectal Polyp: A Case Report with Review of Probable Pathogenesis

Naimi, Azar; Hosseinpour, Mehrdad

Osseous Metaplasia in Rectal Polyp: A Case Report with Review of Probable Pathogenesis

Document Type : CASE REPORT

Authors

Azar Naimi ¹
Mehrdad Hosseinpour ²

¹ Department of Pathology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

² Department of Surgery, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Abstract

Heterotopic bone formation is a rare event in gastrointestinal lesions, especially in the pediatric population. Osseous metaplasia is exceedingly rare in colonic polyps. We present a case of rectal juvenile polyp with stromal osseous metaplasia in a 10-year-old male child. This histologic finding is very rare in children with colorectal polyps.

Keywords

References

1.	Garg M, Kaur J, Bindroo S, Sharma A, Mahajan NC. Metaplastic ossification in a juvenile rectal polyp: A rare histological finding. J Clin Diagn Res 2013;7:908-10. [PUBMED]
2.	Haque S, Eisen RN, West AB. Heterotopic bone formation in the gastrointestinal tract. Arch Pathol Lab Med 1996;120:666-70. [PUBMED]
3.	Nakajima H, Iwane S, Mikami T, Nara H, Yamagata K, Morita T, et al. Osseous metaplasia in benign rectal polyps. J Clin Gastroenterol 1997;25:558-9. [PUBMED]
4.	Bhat V, Roopa A, Shariff S. Juvenile rectal polyp with osseous metaplasia – A rare case with review of literature. Int J Health Sci Res 2012;2:114-6.
5.	Bhattacharya N, Sarkar T. Osseous metaplasia in a juvenile polyp: A rare case report in India. J Clin Diagn Res 2013;7:2004-5. [PUBMED]
6.	Hjelkrem M, Fair K, Pabby A. Osseous metaplasia in a colon polyp. Pract Gastroenterol 2012;36:58-62.
7.	Dukes CE. Ossification in rectal cancer: (Section of surgery: Sub-section of proctology). Proc R Soc Med 1939;32:1489-94. [PUBMED]
8.	Ohtsuki Y, Danbara Y, Takeda I, Takahashi K, Hayashi K, Sonobe H, et al. Metaplastic bone formation in a hyperplastic polyp of the stomach: A case report. Acta Med Okayama 1987;41:43-6. [PUBMED]
9.	Oono Y, Fu KL, Nakamura H, Iriguchi Y, Oda J, Mizutani M, et al. Bone formation in a rectal inflammatory polyp. World J Gastrointest Endosc 2010;2:104-6. [PUBMED]
10.	Narita T, Ohnuma H, Yokoyama S. Peutz-Jeghers syndrome with osseous metaplasia of the intestinal polyps. Pathol Int 1995;45:388-92. [PUBMED]
11.	van Patter HT, Whittick JW. Heterotopic ossification in intestinal neoplasms. Am J Pathol 1955;31:73. [PUBMED]
12.	Sanerkin NG. Squamous metaplasia and ossification in colonic adenocarcinoma. J Pathol Bacteriol 1968;95:547-9. [PUBMED]
13.	Groisman GM, Benkov KJ, Adsay V, Dische MR. Osseous metaplasia in benign colorectal polyps. Arch Pathol Lab Med 1994;118:64-5. [PUBMED]
14.	Kypson AP, Morphew E, Jones R, Gottfried MR, Seigler HF. Heterotopic ossification in rectal cancer: Rare finding with a novel proposed mechanism. J Surg Oncol 2003;82:132-6. [PUBMED]
15.	Wernig M, Meissner A, Foreman R, Brambrink T, Ku M, Hochedlinger K, et al. In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state. Nature 2007;448:318-24. [PUBMED]
16.	Takahashi K, Tanabe K, Ohnuki M, Narita M, Ichisaka T, Tomoda K, et al. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 2007;131:861-72. [PUBMED]
17.	Teot LA, O'Keefe RJ, Rosier RN, O'Connell JX, Fox EJ, Hicks DG. Extraosseous primary and recurrent giant cell tumors: Transforming growth factor-beta1 and -beta2 expression may explain metaplastic bone formation. Hum Pathol 1996;27:625-32.

Advanced Biomedical Research