Advanced Biomedical Research

Serum testosterone and gonadotropins levels in patients with premature ejaculation: A comparison with normal men

Authors

1 Department of Urology, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran

2 Isfahan Urology and Kidney Transplantation Research Center, Al-Zahra Hospital, Isfahan University of Medical Sciences, Isfahan, Iran

Abstract

Background: To investigate the role of testosterone (T) in the pathogenesis of ejaculatory symptoms, particularly premature ejaculation (PE).
Materials and Methods: A total of 41 male patients with PE as well as 41 controls with no sexual dysfunction were recruited in this cross-sectional study. We used the stopwatch measurement to monitor the intravaginal ejaculatory latency time (IELT). Patients with mean IELT values lower than 60 s were considered to have PE. Serum levels of follicle stimulating hormone (FSH), luteinizing hormone (LH), prolactin (PRL), total testosterone (TT) and free testosterone (FT) were measured in patients as well as controls. Patients with thyroid dysfunction, hypogonadism, hypertension and dyslipidemia were excluded from the study.
Results: The serum levels of FT and FSH were significantly higher in cases (P = 0.036 and 0.003, respectively). There was no significant difference between TT, LH and PRL levels of the two groups.
Conclusion: Patients with PE have higher FT and FSH levels compared with normal men. The causative relationship between these entities and also the clinical importance of this finding has to be determined by more comprehensive studies.

Keywords

1. Mercer CH, Fenton KA, Johnson AM, Wellings K, Macdowall W, McManus S, et al. Sexual function problems and help seeking behaviour in Britain: National probability sample survey. BMJ 2003;327:426-7.  Back to cited text no. 1
    
2. Porst H, Montorsi F, Rosen RC, Gaynor L, Grupe S, Alexander J. The premature ejaculation prevalence and attitudes (PEPA) survey: Prevalence, comorbidities, and professional help-seeking. Eur Urol 2007;51:816-23.  Back to cited text no. 2
[PUBMED]    
3. McMahon CG, Abdo C, Incrocci L, Perelman M, Rowland D, Waldinger M, et al. Disorders of orgasm and ejaculation in men. J Sex Med 2004;1:58-65.  Back to cited text no. 3
[PUBMED]    
4. Cihan A, Demir O, Demir T, Aslan G, Comlekci A, Esen A. The relationship between premature ejaculation and hyperthyroidism. J Urol 2009;181:1273-80.  Back to cited text no. 4
[PUBMED]    
5. Vignozzi L, Corona G, Petrone L, Filippi S, Morelli AM, Forti G, et al. Testosterone and sexual activity. J Endocrinol Invest 2005;28:39-44.  Back to cited text no. 5
[PUBMED]    
6. Waldinger MD. Lifelong premature ejaculation: Definition, serotonergic neurotransmission and drug treatment. World J Urol 2005;23:102-8.  Back to cited text no. 6
[PUBMED]    
7. Waldinger MD. The neurobiological approach to premature ejaculation. J Urol 2002;168:2359-67.  Back to cited text no. 7
[PUBMED]    
8. Corona G, Jannini EA, Mannucci E, Fisher AD, Lotti F, Petrone L, et al. Different testosterone levels are associated with ejaculatory dysfunction. J Sex Med 2008;5:1991-8.  Back to cited text no. 8
[PUBMED]    
9. Barrett-Connor E. Lower endogenous androgen levels and dyslipidemia in men with non-insulin-dependent diabetes mellitus. Ann Intern Med 1992;117:807-11.  Back to cited text no. 9
[PUBMED]    
10. Hughes GS, Ringer TV, Watts KC, DeLoof MJ, Francom SF, Spillers CR. Fish oil produces an atherogenic lipid profile in hypertensive men. Atherosclerosis 1990;84:229-37.  Back to cited text no. 10
[PUBMED]    
11. Waldinger MD, Zwinderman AH, Olivier B, Schweitzer DH. Proposal for a definition of lifelong premature ejaculation based on epidemiological stopwatch data. J Sex Med 2005;2:498-507.  Back to cited text no. 11
[PUBMED]    
12. Forti G, Krausz C, Cilotti A, Maggi M. Varicocele and infertility. J Endocrinol Invest 2003;26:564-9.  Back to cited text no. 12
[PUBMED]    
13. Govier FE, Asase D, Hefty TR, McClure RD, Pritchett TR, Weissman RM. Timing of penile color flow duplex ultrasonography using a triple drug mixture. J Urol 1995;153:1472-5.  Back to cited text no. 13
[PUBMED]    
14. Hull EM, Du J, Lorrain DS, Matuszewich L. Testosterone, preoptic dopamine, and copulation in male rats. Brain Res Bull 1997;44:327-33.  Back to cited text no. 14
[PUBMED]    
15. Mooradian AD, Morley JE, Korenman SG. Biological actions of androgens. Endocr Rev 1987;8:1-28.  Back to cited text no. 15
[PUBMED]    
16. Toone BK, Wheeler M, Nanjee M, Fenwick P, Grant R. Sex hormones, sexual activity and plasma anticonvulsant levels in male epileptics. J Neurol Neurosurg Psychiatry 1983;46:824-6.  Back to cited text no. 16
[PUBMED]    
17. Brown WA, Monti PM, Corriveau DP. Serum testosterone and sexual activity and interest in men. Arch Sex Behav 1978;7:97-103.  Back to cited text no. 17
[PUBMED]    
18. Lange JD, Brown WA, Wincze JP, Zwick W. Serum testosterone concentration and penile tumescence changes in men. Horm Behav 1980;14:267-70.  Back to cited text no. 18
[PUBMED]    
19. O'Carroll R, Shapiro C, Bancroft J. Androgens, behaviour and nocturnal erection in hypogonadal men: The effects of varying the replacement dose. Clin Endocrinol (Oxf) 1985;23:527-38.  Back to cited text no. 19
[PUBMED]    
20. Kwan M, Greenleaf WJ, Mann J, Crapo L, Davidson JM. The nature of androgen action on male sexuality: A combined laboratory-self-report study on hypogonadal men. J Clin Endocrinol Metab 1983;57:557-62.  Back to cited text no. 20
[PUBMED]    
21. Mills TM, Wiedmeier VT, Stopper VS. Androgen maintenance of erectile function in the rat penis. Biol Reprod 1992;46:342-8.  Back to cited text no. 21
[PUBMED]    
22. Richardson JD. Male sexual dysfunction. Ejaculatory problems. Aust Fam Physician 1993;22:1367-70.  Back to cited text no. 22
[PUBMED]    
23. Yassin AA, Saad F. Improvement of sexual function in men with late-onset hypogonadism treated with testosterone only. J Sex Med 2007;4:497-501.  Back to cited text no. 23
[PUBMED]    
24. Morelli A, Corona G, Filippi S, Ambrosini S, Forti G, Vignozzi L, et al. Which patients with sexual dysfunction are suitable for testosterone replacement therapy? J Endocrinol Invest 2007;30:880-8.  Back to cited text no. 24
    
25. Traish AM, Guay AT. Are androgens critical for penile erections in humans? Examining the clinical and preclinical evidence. J Sex Med 2006;3:382-404.  Back to cited text no. 25
[PUBMED]    
26. Corona G, Mannucci E, Petrone L, Giommi R, Mansani R, Fei L, et al. Psycho-biological correlates of hypoactive sexual desire in patients with erectile dysfunction. Int J Impot Res 2004;16:275-81.  Back to cited text no. 26
[PUBMED]    
27. Corona G, Petrone L, Mannucci E, Ricca V, Balercia G, Giommi R, et al. The impotent couple: Low desire. Int J Androl 2005;28 Suppl 2:46-52.  Back to cited text no. 27
[PUBMED]    
28. Corona G, Ricca V, Bandini E, Mannucci E, Petrone L, Fisher AD, et al. Association between psychiatric symptoms and erectile dysfunction. J Sex Med 2008;5:458-68.  Back to cited text no. 28
    
29. Corona G, Mannucci E, Fisher AD, Lotti F, Ricca V, Balercia G, et al. Effect of hyperprolactinemia in male patients consulting for sexual dysfunction. J Sex Med 2007;4:1485-93.  Back to cited text no. 29
[PUBMED]    
Advanced Biomedical Research
Volume 2014, January
January 2014
Pages 1-4