Primary esophageal small cell neuroendocrine carcinoma in a child: A case report with review on demography, presentation, treatment, and survival

Authors

1 Department of Pathology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

2 Department of Radiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Abstract

Primary gastrointestinal small cell carcinoma is reported 0.1%–1.0% of malignant gastrointestinal tumors and predominantly in the esophagus. All reported cases are in the adult population. We present a 9-year-old boy with small cell neuroendocrine carcinoma of the esophagus with mediastinal lymph node involvement, whose chief complaint was progressive dysphagia. He survived for 22 months with chemoradiation but did not have resectional surgery. Although small cell neuroendocrine carcinoma of the esophagus is extremely rare in children, it should be considered in the differential diagnosis of any undifferentiated tumor of the esophagus in any age.

Keywords

1.
Farooqui ZA, Chauhan A. Neuroendocrine tumors in pediatrics. Glob Pediatr Health 2019;6:2333794X19862712. eCollection 2019.  Back to cited text no. 1
    
2.
Hosseini S, Salek R, Nasrolahi H, Mohammadianpanah M, Judi M. Small cell carcinoma of the esophagus: Clinicopathological features and outcome of 22 cases. Iran Red Crescent Med J 2015;17:e20353.  Back to cited text no. 2
    
3.
Lv J, Liang J, Wang J, Wang L, He J, Xiao Z, et al. Primary small cell carcinoma of the esophagus. J Thorac Oncol 2008;3:1460-5.  Back to cited text no. 3
    
4.
Lari M, Khossravy A, Ghiassi T. Carcinoma of the esophagus in a fourteen year old boy. Med J Islam Repub Iran 1995;8:277-80.  Back to cited text no. 4
    
5.
Egashira A, Morita M, Kumagai R, Taguchi KI, Ueda M, Yamaguchi S, et al. Neuroendocrine carcinoma of the esophagus: Clinicopathological and immunehistochemical features of 14 cases. PLoS One 2017;12:e0173501.  Back to cited text no. 5
    
6.
Ye L, Lu H, Wu L, Zhang L, Shi H, Wu HM, et al. The clinicopathologic features and prognosis of esophageal neuroendocrine carcinomas: A single-center study of 53 resection cases. BMC Cancer 2019;19:1234.  Back to cited text no. 6
    
7.
Jeene PM, Geijsen ED, Muijs CT, Rozema T, Aleman BM, Muller K, et al. Small cell carcinoma of the esophagus: A nationwide analysis of treatment and outcome at patient level in locoregional disease. Am J Clin Oncol 2019;42:534-8.  Back to cited text no. 7
    
8.
Chen WW, Wang F, Chen S, Wang L, Ren C, Luo HY, et al. Detailed analysis of prognostic factors in primary esophageal small cell carcinoma. Ann Thorac Surg 2014;97:1975-81.  Back to cited text no. 8
    
9.
Kuo CH, Hsieh CC, Chan ML, Li AF, Huang MH, Hsu WH, et al. Small cell carcinoma of the esophagus: A report of 16 cases from a single institution and literature review. Ann Thorac Surg 2011;91:373-8.  Back to cited text no. 9
    
10.
Jatoi A, Miller RC. Should we recommend surgery to patients with limited small cell carcinoma of the esophagus? J Thorac Oncol 2008;3:1373-6.  Back to cited text no. 10