The Role of Mas Receptor on Renal Hemodynamic Responses to Angiotensin 1-7 in Both Irreversible and Reversible Unilateral Ureteral Obstruction Rats

Haghani, Fariba; Soltani Arabshahi, Seyed Kamran; Bigdeli, Shoaleh; Alavi, Mousa; Omid, Athar; Hassanshahi, Jalal; Nematbakhsh, Mehdi

The Role of Mas Receptor on Renal Hemodynamic Responses to Angiotensin 1-7 in Both Irreversible and Reversible Unilateral Ureteral Obstruction Rats

Authors

¹ Department of Medical Education, Medical Education Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

² Department of Medical Education, Faculty of Medicine, Center for Educational Research in Medical Sciences, Tehran University of Medical sciences, Tehran, Iran

³ Nursing and midwifery Care Research Center, Faculty of Nursing & Midwifery, Isfahan University of Medical Sciences, Isfahan, Iran

⁴ Water and Electrolytes Research Center, Isfahan University of Medical Sciences; Department of Physiology, Isfahan University of Medical Sciences, Isfahan, Iran

⁵ Water and Electrolytes Research Center, Isfahan University of Medical Sciences; Department of Physiology, Isfahan University of Medical Sciences; IsfahanMN Institute of Basic and Applied Sciences Research, Isfahan, Iran

Abstract

Background: Unilateral ureteral obstruction (UUO) alters the expression of renin-angiotensin system (RAS) components and angiotensin 1-7 (Ang 1-7) as a main arm of RAS is affected by UUO. The role of Mas receptor antagonist (A779) was examined in renal hemodynamic responses to Ang 1-7 in 3-day UUO and UUO removal (RUUO) in rats. Materials and Methods: Forty-five male Wistar rats were randomly divided into three groups of sham operated, UUO, and RUUO, while each group was divided into two subgroups treated with vehicle or A779. Renal blood flow (RBF) and renal vascular resistance (RVR) responses to graded Ang 1-7 infusion were measured at controlled renal perfusion pressure. Results: Mean arterial pressure response to Ang 1-7 was increased in vehicle-treated subgroup significantly (P < 0.05) when compared with A779-treated subgroup. However, such observation was not seen in UUO and RUUO rats. The graded Ang 1-7 infusion increased RBF and decreased RVR significantly in vehicle-treated rats (P < 0.005). Furthermore, a significant difference was found between vehicle and A779-treated subgroups in sham, UUO, and RUUO groups (P < 0.005). Conclusion: Ang 1-7 could alter the kidney hemodynamics responses in ureteral obstruction models.

Keywords

References

1.	Vaughan ED Jr., Marion D, Poppas DP, Felsen D. Pathophysiology of unilateral ureteral obstruction: Studies from charlottesville to New York. J Urol 2004;172:2563-9.
2.	Tavukçu HH, Tinay İ, Tarcan T. To save or not to save the kidney: Relieving unilateral obstruction may significantly improve an initially low split renal creatinine clearance. J Urol Surg 2016;3:7-12.
3.	Gulmi FA, Felsen D. Pathophysiology of urinary tract obstruction. Smith's Textbook of Endourology. Vol. 12. West Sussex (United Kingdom): Wiley-Blackwell; 2012. p. 95-119.
4.	Hvistendahl JJ, Pedersen TS, Djurhuus JC, Pedersen EB, Frøkiaer J. Losartan attenuates renal vasoconstriction in response to acute unilateral ureteral occlusion in pigs. Urol Res 2002;30:169-77.
5.	Santos RA, Ferreira AJ. Angiotensin-(1-7) and the renin-angiotensin system. Curr Opin Nephrol Hypertens 2007;16:122-8. [PUBMED]
6.	Santos RA, Simoes e Silva AC, Maric C, Silva DM, Machado RP, de Buhr I, et al. Angiotensin-(1-7) is an endogenous ligand for the G protein-coupled receptor mas. Proc Natl Acad Sci U S A 2003;100:8258-63. [PUBMED]
7.	Pinheiro SV, Simões e Silva AC, Sampaio WO, de Paula RD, Mendes EP, Bontempo ED, et al. Nonpeptide AVE 0991 is an angiotensin-(1-7) receptor mas agonist in the mouse kidney. Hypertension 2004;44:490-6.
8.	Zimmerman D, Burns KD. Angiotensin-(1-7) in kidney disease: A review of the controversies. Clin Sci (Lond) 2012;123:333-46. [PUBMED]
9.	Jawien J, Toton-Zuranska J, Gajda M, Niepsuj A, Gebska A, Kus K, et al. Angiotensin-(1-7) receptor Mas agonist ameliorates progress of atherosclerosis in apoE-knockout mice. Atherosclerosis 2012;1:4.
10.	Zhang J, Noble NA, Border WA, Huang Y. Infusion of angiotensin-(1-7) reduces glomerulosclerosis through counteracting angiotensin II in experimental glomerulonephritis. Am J Physiol Renal Physiol 2010;298:F579-88. [PUBMED]
11.	Zimmerman DL, Zimpelmann J, Xiao F, Gutsol A, Touyz R, Burns KD, et al. The effect of angiotensin-(1-7) in mouse unilateral ureteral obstruction. Am J Pathol 2015;185:729-40.
12.	Esteban V, Heringer-Walther S, Sterner-Kock A, de Bruin R, van den Engel S, Wang Y, et al. Angiotensin-(1-7) and the g protein-coupled receptor MAS are key players in renal inflammation. PLoS One 2009;4:e5406. [PUBMED]
13.	Radović N, Aralica G, Ljubanović DG, Jelec V, Kontek M. Effect of unilateral ureteral obstruction and anti-angiotensin II treatment on renal tubule cell apoptosis and interstitial fibrosis in rats. Coll Antropol 2014;38:583-8.
14.	Nematbakhsh M, Safari T. Role of mas receptor in renal blood flow response to angiotensin (1-7) in male and female rats. Gen Physiol Biophys 2014;33:365-72. [PUBMED]
15.	Saberi S, Dehghani A, Nematbakhsh M. Role of mas receptor in renal blood flow response to angiotensin-(1-7) in ovariectomized estradiol treated rats. Res Pharm Sci 2016;11:65-72. [PUBMED]
16.	Mansoori A, Oryan S, Nematbakhsh M. Role of mas receptor antagonist (A779) on pressure diuresis and natriuresis and renal blood flow in the absence of angiotensin II receptors type 1 and 2 in female and male rats. J Physiol Pharmacol 2014;65:633-9. [PUBMED]
17.	Kim CS, Kim IJ, Bae EH, Ma SK, Lee J, Kim SW, et al. Angiotensin-(1-7) attenuates kidney injury due to obstructive nephropathy in rats. PLoS One 2015;10:e0142664.
18.	Arnold AC, Shaltout HA, Gilliam-Davis S, Kock ND, Diz DI. Autonomic control of the heart is altered in sprague-dawley rats with spontaneous hydronephrosis. Am J Physiol Heart Circ Physiol 2011;300:H2206-13. [PUBMED]
19.	Sampaio WO, Nascimento AA, Santos RA. Systemic and regional hemodynamic effects of angiotensin-(1-7) in rats. Am J Physiol Heart Circ Physiol 2003;284:H1985-94. [PUBMED]
20.	Zimmerman D. The Role of Angiotensin-(1-7) in a Mouse Model of Renal Fibrosis. University of Ottawa (Canada); 2013.
21.	Pinheiro SV, Ferreira AJ, Kitten GT, da Silveira KD, da Silva DA, Santos SH, et al. Genetic deletion of the angiotensin-(1-7) receptor mas leads to glomerular hyperfiltration and microalbuminuria. Kidney Int 2009;75:1184-93. [PUBMED]
22.	Ren Y, Garvin JL, Carretero OA. Vasodilator action of angiotensin-(1-7) on isolated rabbit afferent arterioles. Hypertension 2002;39:799-802. [PUBMED]
23.	Bosnyak S, Jones ES, Christopoulos A, Aguilar MI, Thomas WG, Widdop RE, et al. Relative affinity of angiotensin peptides and novel ligands at AT1 and AT2 receptors. Clin Sci (Lond) 2011;121:297-303.
24.	Stegbauer J, Vonend O, Oberhauser V, Rump LC. Effects of angiotensin-(1-7) and other bioactive components of the renin-angiotensin system on vascular resistance and noradrenaline release in rat kidney. J Hypertens 2003;21:1391-9. [PUBMED]
25.	Ito K, Chen J, El Chaar M, Stern JM, Seshan SV, Khodadadian JJ, et al. Renal damage progresses despite improvement of renal function after relief of unilateral ureteral obstruction in adult rats. Am J Physiol Renal Physiol 2004;287:F1283-93. [PUBMED]
26.	Maleki M, Nematbakhsh M. Renal blood flow response to angiotensin 1-7 versus hypertonic sodium chloride 7.5% administration after acute hemorrhagic shock in rats. Int J Vasc Med 2016;2016:6562017. [PUBMED]

Advanced Biomedical Research