Advanced Biomedical Research

Gestational throphoblastic diseases in North East of Iran: 10 years (2001-2010) prospective epidemiological and clinicopathological study

Authors

1 Cancer Research Center , Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

2 Pathologist, Faculty of Medicine, birjand university of medical sciences, Mashhad, Iran

3 Medical Student, Mashhad University of Medical Sciences, Mashhad, Iran

Abstract

Background: Many aspects of epidemiological and clinicopathological features of gestational trophoblastic disease (GTD), one of the important subject in gynecology oncology, needs to be defined so as to recommend the best approach and management toward it. In the present study, we evaluated 10-years incidence of throphoblastic diseases in north east of Iran in prospective epidemiological and clinicopathological study.
Materials and Methods:We reviewed the registered histopathology database archive (120 records) related to throphoblastic diseases of the Ghaem Hospital, Mashhad University of Medical Sciences from 2001 to 2010.
Results:Evaluation of the pathological reports revealed 5 (4.2%) choriocarcinom and 115 (95.8%) of hydatidiform mole (HM), with complete and partial HM diagnosis in 29 (25.2%) and 86 (74.8%) patients, respectively. The pregnancy rate of HM patients (2.72 ± 1.86) and choriocarcinoma patients (3.56 ± 2.8) was not significantly different ( P = 0.61). There was no statistical significant difference between the number of pregnancies in HM (2.90 ± 3.13) and choriocarcinoma (3.84 ± 3.80) patients ( P = 0.46). The ratio of complete to partial mole increased with age, although this correlation was not significant. Most patients in both the groups had no history of abortion. O positive was the predominant blood group among the studied patients.
Conclusion:Throphoblastic diseases occur during the fertility age mostly, and there is an increased risk with more previous pregnancies; ultrasound sonography is a useful method for primary diagnosis of this disease. Further pathological studies are needed to define the mole type.

Keywords

1. Goldstein DP, Berkowitz RS. Gestational trophoblastic neoplasms: Clinical principles of diagnosis and management. Major Probl Obstet Gynecol 1982;14:1-301.  Back to cited text no. 1
[PUBMED]    
2. Goldstein DP, Berkowitz RS. Gestational trophoblastic diseases. In: DeVita, Vincent T, Lawrence A, Theodore S. Rosenberg S, Steven DA, editors. Hellman, and Rosenberg's Cancer: Principles and Practice of Oncology. 9th ed. Lippincott: Williams and Wilkins; 2011. p. 1363.  Back to cited text no. 2
    
3. Shih LeM, Mazur MT, Kurman RJ. Gestational trophoblastic disease and related lesions. In: Kurman Robert J, editor. Blaustein's pathology of the female genital tract. New York: Springer: 5 th ed., 2002. p. 1193-247.  Back to cited text no. 3
    
4. Garner EI, Goldstein DP, Feltmate CM, Berkowitz RS. Gestational trophoblastic disease. Clin Obstet Gynecol 2007;50:112-22.  Back to cited text no. 4
    
5. Garner EI, Lipson E, Bernstein MR, Goldstein DP, Berkowitz RS. Subsequent pregnancy experience in patients with molar pregnancy and gestational trophoblastic tumor. J Reprod Med 2002;47:380-6.  Back to cited text no. 5
    
6. Altieri A, Franceschi S, Ferlay J, Smith J, La Vecchia C. Epidemiology and aetiology of gestational trophoblastic diseases. Lancet Oncol 2003;4:670-8.  Back to cited text no. 6
    
7. Steigrad SJ. Epidemiology of gestational trophoblastic diseases. Best Pract Res Clin Obstet Gynaecol 2003;17:837-47.  Back to cited text no. 7
    
8. Smith HO. Gestational trophoblastic disease epidemiology and trends. Clin Obstet Gynecol 2003;46:541-56.  Back to cited text no. 8
    
9. Bracken MB, Brinton LA, Hayashi K. Epidemiology of hydatidiform mole and choriocarcinoma. Epidemiol Rev 1984;6:52-75.  Back to cited text no. 9
    
10. Berkowitz RS, Cramer DW, Bernstein MR, Cassells S, Driscoll SG, Goldstein DP. Risk factors for complete molar pregnancy from a case-control study. Am J Obstet Gynecol 1985;152:1016-20.  Back to cited text no. 10
    
11. Mosher R, Goldstein DP, Berkowitz R, Bernstein M, Genest DR. Complete hydatidiform mole. Comparison of clinicopathologic features, current and past. J Reprod Med 1998;43:21-7.  Back to cited text no. 11
    
12. Bracken MB. Incidence and aetiology of hydatidiform mole: An epidemiological review. Br J Obstet Gynaecol 1987;94:1123-35.  Back to cited text no. 12
    
13. Semer DA, Macfee MS. Gestational trophoblastic disease: Epidemiology. Semin Oncol 1995;22:109-12.  Back to cited text no. 13
    
14. Gestational trophoblastic diseases. Report of a WHO scientific group. World Health Organ Tech Rep Ser 1983;692:7-81.  Back to cited text no. 14
    
15. Flam F, Rutqvist LE. Under-registration of gestational trophoblastic disease in the Swedish Cancer Registry. Eur J Epidemiol 1992;8:683-6.  Back to cited text no. 15
    
16. Benson CB, Genest DR, Bernstein MR, Soto-Wright V, Goldstein DP, Berkowitz RS. Sonographic appearance of first trimester complete hydatidiform moles. Ultrasound Obstet Gynecol 2000;16:188-91.  Back to cited text no. 16
    
17. Oge T, Ozalp SS, Güngör T, Yildirim Y, Sanci M, Dogan A, et al. Hydatidiform mole in Turkey: Results from six centers. J Reprod Med 2012;57:259-61.  Back to cited text no. 17
    
18. Rolon PA, Hochsztajn de Lopez B. Malignant trophoblastic disease in paraguay. J Reprod Med 1979;23:94-6.  Back to cited text no. 18
    
19. Lazoviæ B, Milenkoviæ V, Dordeviæ S. Treatment of gestational trophoblastic disease-a 10-year experience. Med Pregl 2012;65:244-6.  Back to cited text no. 19
    
20. Tham BW, Everard JE, Tidy JA, Drew D, Hancock BW. Gestational trophoblastic disease in the Asian population of Northern England and North Wales. BJOG 2003;110:555-9.  Back to cited text no. 20
    
21. Altman AD, Bentley B, Murray S, Bentley JR. Maternal age-related rates of gestational trophoblastic disease. Obstet Gynecol 2008;112:244-50.  Back to cited text no. 21
    
22. Bagshawe KD, Dent J, Webb J. Hydatidiform mole in England and Wales 1973-83. Lancet 1986;2:673-7.  Back to cited text no. 22
    
23. Nowak-Markwitz E, Drews K, Spaczyñski M. Gestational trophoblastic disease: The epidemiological analysis of 342 cases. Ginekol Pol 2000;71:767-72.  Back to cited text no. 23
    
24. Mohammadjafari R, Abedi P, Tadayon M. The Gestational Trophoblastic Diseases: A Ten Year Retrospective Study. IJFS 2010;4:1-4.  Back to cited text no. 24
    
25. Jain KA. Gestational trophoblastic disease: Pictorial review. Ultrasound Q 2005;21:245-53.  Back to cited text no. 25
    
26. Grimes DA. Epidemiology of gestational trophoblastic disease. Am J Obstet Gynecol 1984;150:309-18.  Back to cited text no. 26
    
27. Parazzini F, La Vecchia C, Franceschi S, Pampallona S, Decarli A, Mangili G, et al. ABO blood-groups and the risk of gestational trophoblastic disease. Tumori 1985;71:123-6.  Back to cited text no. 27
    
Advanced Biomedical Research
Volume 2014, January
January 2014
Pages 1-4