Advanced Biomedical Research

An insight into genetics of non-syndromic cleft palate

Authors

1 Medical Genetics Laboratory, Alzahra University Hospital; Pediatric Inherited Disease Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

2 Department of Genetics and Molecular Biology, Medical School, Isfahan University of Medical Sciences, Isfahan, Iran

3 Pediatric Surgery Department, Emam Hossein Hospital, Isfahan University of Medical Sciences, Isfahan, Iran

4 Medical Genetics Laboratory, Alzahra University Hospital, Isfahan University of Medical Sciences, Isfahan, Iran

Abstract

Our proband is a 29-year-old man, who is affected with soft cleft palate and hypernasality. A study of about six generations of this family pedigree shows that cleft palate has repeatedly occurred in males, with probably a X-linked recessive pattern of inheritance. Interestingly, the sister of the proband is affected with hypernasality and she has an affected son. This is the first report of X-linked inheritance pattern of cleft palate in Iran.

Keywords

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Advanced Biomedical Research
Volume 2013, March
March 2013
Pages 1-4