Recent advances in the field of antimicrobial peptides in inflammatory diseases


Department of Immunology, National School of Biological Sciences, National Polytechnic Institute, Mexico, D.F., Mexico


Antimicrobial peptides are cationic molecules, which participate in multiple aspects of the immune response
including the control of inflammatory diseases, characteristic that make these molecules attractive as
therapeutic tools. These peptides are produced in bacteria, insects, plants and vertebrates, and are classified
together due to their capacity to directly inhibit the growth of microorganisms, and to regulate the immune
response by inducing the secretion of chemokines and cytokines. Various families of antimicrobial peptides
have been identified including the cathelicidins and defensins, the most investigated human antimicrobial
peptides. This review will cover the main biological functions of antimicrobial and cell-penetrating peptides
in inflammation, and describe the importance and utility of antimicrobial peptides as therapeutics for
inflammatory diseases. 


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