Serum selenium levels in chronic lymphocytic leukemia

Authors

1 Department of Hematology and Oncology, Hematology and Oncology Center, Isfahan University of Medical Sciences, Isfahan, Iran

2 Department of Biochemistry, Payame Nour University of Isfahan, Isfahan, Iran

3 Department of Biology, Botany science, Isfahan University, Isfahan, Iran

4 Department of Cellular and Molecular Biology, Isfahan, Iran

Abstract

Background: Selenium is a trace mineral which has the role of multiple biologic functions. In free-living animals and humans, selenium is mostly in the form of two selenium-containing amino acids as selenocysteine and selenomethionine. The present study aimed to obtain more data on the relationship between serum selenium in chronic lymphocytic leukemia (CLL).
Materials and Methods: Serum selenium levels were measured in 51 patients with chronic lymphocytic leukemia (CLL) as patients group and in 40 non-hospitalized healthy individuals as control group.
Results: Selenium was recognized by atomic absorption spectrometer. Decreased mean serum selenium concentrations were observed in the group with chronic lymphocytic leukemia as compared to normal ones ( P = 0.005). Serum selenium concentrations were examined in stages 0 and I. They observed a significant difference between the mean serum concentrations of selenium in stage 0, I and II and that of stage IV and V patients with CLL ( P = 0.01). The groups were compared and significant differences were observed i.e., low serum selenium levels in the stage III and IV CLL ( P = 0.001). The second selenium test was designed in 21 out of 48 patients within 10 weeks from the beginning of chemotherapy. Serum selenium concentration was tested again in 21 patients, and significant differences have been observed between the time before the treatment and after it ( P = 0.02).
Conclusions: Our results show that in patients with CLL the mean serum selenium levels are lower than that of normal.

Keywords

1. Spallholz JE, Boylan LM, Larsen HS. Advances in understanding selenium's role in the immune system. Ann N Y Acad Sci 1990;587:123.  Back to cited text no. 1
    
2. Beguin Y, Delbrouck J-M, Robaye G, et al: Correlation of serum trace elements with other biological parameters in hemoproliferative disorders, in Bratter P, Schramel P, eds. Trace Element Analytical Chemistry in Medicine and Biology, Vol 4. Berlin, Germany, Walter de Gruyter, 1987, pp 537-45.  Back to cited text no. 2
    
3. Shamberger RJ, Rukovena E, Longfield AK, Tytko SA, Deodhar S, Willis CE. Antioxidants and cancer. I. Selenium in the blood of normals and cancer patients. J Natl Cancer Inst 1973;50:863-70.  Back to cited text no. 3
    
4. Hardell L, Degerman A, Tomic R, Marklund SL, Berg fors M. Level of selenium in plasma and glutathione peroxidase in erythrocytes in patients with prostate cancer or benign hyperplasia. Eur J Cancer Prev 1995;4:91-5.  Back to cited text no. 4
    
5. McConnel KP, Broghamer WL Jr, Blotcky AJ, Hurt J. Selenium levels in human blood and tissue in health and disease. J Nutr 1975;105:1026-31.  Back to cited text no. 5
    
6. Holben DH, Smith AM. The diverse role of selenium within selenoproteins: A review. J Am Diet Assoc 1999;99:836-43.  Back to cited text no. 6
    
7. Rotrack JT, Pope AL, Ganther HE, Swans AB, Hafeman DG, Hoekstra WG. PERONA Selenium: Biochemical role as a component of glutathione peroxidase. Science 1973;179:588-90.  Back to cited text no. 7
    
8. Last KW, Cornelius V, Delves T, Sieniawska C, Fitzqibbon J, Norton A, et al. Presentation serum selenium predicts for overall survival, dose delivery, and first treatment response in aggressive non-Hodgkin's lymphoma. J Clin Oncol 2003;21:2335-41.  Back to cited text no. 8
    
9. Beguin Y, Brasseur F, Weber G, Bury J, Delbrouck JM, Roelandts I, et al. Observations of serum traceelements in chronic lymphocytic leukemia. Cancer 1987;60:1842-6.  Back to cited text no. 9
    
10. Avanzini P, Vinceti M, Ilariucci F, Masini L, D'Incà M, Vivoli G. Serum selenium concentrations in patients with newly diagnosed lymphoid malignancies. Haematologica 1995;80:505-11.  Back to cited text no. 10
    
11. Baur G, Wendel A. The activity of the peroxide-metabolizing system in human colon carcinoma. J Cancer Res Clin Oncol 1980;97:267-73.  Back to cited text no. 11
    
12. Itoh T, Kobayashi M, Tazawa T, Satoh H, Saito K. Selenium concentrations in gastric tissues of the patients with stomach cancer. J Trace Elem Exp Med 1989;2:160-1.  Back to cited text no. 12
    
13. Herrera NE, Gonzalez R, Schwartz RD, Diggs AM, Belsky J. Se methionine as a diagnostic agent in malignant lymphoma. J Nucl Med 1965;6:792-804.  Back to cited text no. 13
    
14. Hara T, Tilbury S, Freed BR, Wooddard HQ, Laughlin JS. Production of 73 Se in cyclotron and its uptake in tumors of mice. Int J Appl Radiat Isot 1973;24:377-384.  Back to cited text no. 14
    
15. Sundström H, Yrjänheikki E, Kauppila A. Serum selenium in patients with ovarian cancer during and after therapy. Carcinogenesis 1984;5:731-4.  Back to cited text no. 15
    
16. Herrera NE, Gonzalez RD, Kranwinkel RN. Further investigations on the role of selenomethionine Se 75 uptake in the diagnosis of lymphoma. Lahey Clin Found Bull 1968;17:43-9.  Back to cited text no. 16
    
17. Nordman E, Jaszsagi-Nagy E, Rekonen A. Changes in tumor cell selenite (75Se) affinity due to irradiation. Ann Clin Res 1976;8:43-7.  Back to cited text no. 17
    
18. Beguin Y, Brasseur F, Weber G, Bury J, Delbrouck JM, Roelandts I, et al. Observations of serum trace elements in chronic lymphocytic leukemia. Cancer 1987;60:1842-6.  Back to cited text no. 18
    
19. Robinson MF, Godfrey PJ, Thomson CD, Rea HM, van Rij AM. Blood selenium and glutathione peroxidase activity in normal subjects and in surgical patients with and without cancer in New Zealand. Am J Clin Nutr 1979;32:1477-85.  Back to cited text no. 19
    
20. Akesson B. Plasma selenium in patients with abnormal plasma protein patterns. Trace Elem Med 1987;4:77-9.  Back to cited text no. 20
    
21. Broghamer WL, McConnel KP, Grimaldi M, Blotcky AJ. Serum selenium and reticuloendothelial tumors. Cancer 1978;41:1462-6.  Back to cited text no. 21
    
22. Deagen JT, Beilstein MA, Whanger PD. Chemical forms of selenium containing proteins from human plasma. J Inorg Biochem 1991;41:261-8  Back to cited text no. 22
    
23. Schroeder HA, Mitchener M. Selenium and tellurium in rats: Effect on growth, survival and tumors. J Nutr 1971;101:1531-40.  Back to cited text no. 23