Comparison of Alopecia severity and blood level of testosterone in men suffering schizophrenia with control group

Authors

Department of Psychiatry, Behavioral Sciences Research Center, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Abstract

Background: Testosterone causes Alopecia that is related to functional testosterone and end organ sensitivity to testosterone. Studies conducted on the relationship of schizophrenia and testosterone have reported different findings. This study was designed to measure the extent of Alopecia in schizophrenic patients which is one of the most important signs of sensitivity to Androgens.
Materials and Methods : In a cross-sectional study, 98 schizophrenic patients and 95 person of normal population encountered to study in two groups considering inclusion criteria and completing a consent form, in the psychiatric ward of Noor Hospital in Isfahan, Iran. Meanwhile, the record of necessary demographic information a blood sample was taken from every selected person to measure the blood level of testosterone. The severity of Alopecia was measured using Hamilton and Norwood criterion in a blindness condition. Collected data were analyzed using SPSS 19 software and statistical tests of χ2 and logistic Regression.
Results: The mean blood level of testosterone in both studied and control groups were 458.80 ± 103 and 476.34 ± 108, respectively, having no significant difference ( P > 0.05). There was no significant relationship in both groups between Alopecia severity and the blood level of testosterone. And in comparison of two groups, providing Androgenic Alopecia with a degree higher than three in Hamilton Scale, schizophrenia risk decreases 8.627 times.
Conclusion: Sensitivity to Androgens and Alopecia probably plays a protective role against schizophrenia, and if Alopecia rate exceeds the rate of grade 2 Hamilton, the risk of schizophrenia decreases 8.62 times.

Keywords

1. Kaplan HI, Sadock BJ. Synopsis of psychiatry, behavioral science clinical psychiatry. New York: Williams and Wilkins; 2007. p. 468-70.  Back to cited text no. 1
    
2. Kaplan HI, Sadock BJ. Shizophrenia Comprehensive Textbook of Psychiatry. New York: Williams and Wilkins; 2009. p. 1432-3.  Back to cited text no. 2
    
3. Ko YH, Jung SW, Joe SH, Lee CH, Jung HG, Jung IK, et al. Association between serum testosterone levels and the severity of negative symptoms in male patients with chronic schizophrenia. Psychoneuroendocrinology 2007;32:385-91.  Back to cited text no. 3
[PUBMED]    
4. Marx CE, Lieberman JA. Psychoneuroendocrinology of schizophrenia. Psychiatr Clin North Am 1998;21:413-34.  Back to cited text no. 4
[PUBMED]    
5. Stevens JR. Schizophrenia: Reproductive hormones and the brain. Am J Psychiatry 2002;159:713-9.  Back to cited text no. 5
[PUBMED]    
6. Brown JS Jr. Effects of bisphenol-A and other endocrine disruptors compared with abnormalities of schizophrenia: An endocrine-disruption theory of schizophrenia. Schizophr Bull 2009;35:256-78.  Back to cited text no. 6
[PUBMED]    
7. Rinieris P, Hatzimanolis J, Markianos M, Stefanis C. Effects of treatment with various doses of haloperidol on the pituitary-gonadal axis in male schizophrenic patients. Neuropsychobiology 1989;22:146-9.  Back to cited text no. 7
[PUBMED]    
8. Kaneda Y, Fujii A. Effects of chronic neuroleptic administration on the hypothalamo-pituitary-gonadal axis of male schizophrenics. Prog Neuropsychopharmacol Biol Psychiatry 2000;24:251-8.  Back to cited text no. 8
[PUBMED]    
9. Kaneda Y. Effects of risperidone on gonadal axis hormones in schizophrenia. Ann Pharmacother 2001;35:1523-7.  Back to cited text no. 9
[PUBMED]    
10. Taherianfard M, Shariaty M. Evaluation of serum steroid hormones in schizophrenic patients. Indian J Med Sci 2004;58:3-9.  Back to cited text no. 10
[PUBMED]  Medknow Journal  
11. Brophy MH, Rush AJ, Crowley G. Cortisol, estradiol, and androgens in acutely ill paranoid schizophrenics. Biol Psychiatry 1983;18:583-90.  Back to cited text no. 11
[PUBMED]    
12. Oades RD, Schepker R. Serum gonadal steroid hormones in young schizophrenic patients. Psychoneuroendocrinology 1994;19:373-85.  Back to cited text no. 12
[PUBMED]    
13. Harris DS, Wolkowitz OM, Reus VI. Movement disorder, memory, psychiatric symptoms and serum DHEA levels in schizophrenic and schizoaffective patients. World J Biol Psychiatry 2001;2:99-102.  Back to cited text no. 13
[PUBMED]    
14. Ritsner M, Maayan R, Gibel A, Strous RD, Modai I, Weizman A. Elevation of the cortisol/dehydroepiandrosterone ratio in schizophrenia patients. Eur Neuropsychopharmacol 2004;14:267-73.  Back to cited text no. 14
    
15. Shirayama Y, Hashimoto K, Suzuki Y, Higuchi T. Correlation of plasma neurosteroid levels to the severity of negative symptoms in male patients with schizophrenia. Schizophr Res 2002;58:69-74.  Back to cited text no. 15
[PUBMED]    
16. Goyal RO, Sagar R, Ammini AC, Khurana ML, Alias AG. Negative correlation between negative symptoms of schizophrenia and testosterone levels. Ann N Y Acad Sci 2004;1032:291-4.  Back to cited text no. 16
[PUBMED]    
17. Akhondzadeh S, Rezaei F, Larijani B, Nejatisafa AA, Kashani L, Abbasi SH. Correlation between testosterone, gonadotropins and prolactin and severity of negative symptoms in male patients with chronic schizophrenia. Schizophr Res 2006;84:405-10.  Back to cited text no. 17
[PUBMED]    
18. Gray A, Feldman HA, McKinlay JB, Longcope C. Age, disease, and changing sex hormone levels in middle-aged men: Results of the massachusetts male aging study. J Clin Endocrinol Metab 1991;73:1016-25.  Back to cited text no. 18
[PUBMED]    
19. Bremner WJ, Vitiello MV, Prinz PN. Loss of circadian rhythmicity in blood testosterone levels with aging in normal men. J Clin Endocrinol Metab 1983;56:1278-81.  Back to cited text no. 19
[PUBMED]    
20. Guyton AC, Hall JE. Testosterone and Other Male Sex Hormones. Textbook of Medical Physiology. Philadelphia: Saunders; 2006. p. 1003-4.  Back to cited text no. 20
    
21. Habif T.P. Clinical Dermatology: A Color Guide to Diagnosis and Therapy. Hanofer: Mosby; 2003. p. 834-839.  Back to cited text no. 21
    
22. Wang TL, Zhou C, Shen YW, Wang XY, Ding XL, Tian S, et al. Prevalence of androgenetic alopecia in China: A community-based study in six cities. Br J Dermatol 2010;162:843-7.  Back to cited text no. 22
[PUBMED]    
23. Guarrera M, Cardo P, Arrigo P, Rebora A. Reliability of hamilton-norwood classification. Int J Trichology 2009;1:120-2.  Back to cited text no. 23
[PUBMED]    
24. Ludwig E. Classification of the types of androgenetic alopecia (common baldness) occurring in the female sex. Br J Dermatol 1977;97:247-54.  Back to cited text no. 24
[PUBMED]    
25. Taylor R, Matassa J, Leavy JE, Fritschi L. Validity of self reported male balding patterns in epidemiological studies. BMC Public Health 2004;4:60-5.  Back to cited text no. 25
[PUBMED