Glomerular filtration rate and urine osmolality in unilateral ureteropelvic junction obstruction


1 Department of Pediatric Nephrology, Isfahan Kidney Diseases Research Center, Isfahan Child Growth and Development Research Center, Isfahan, Iran

2 Department of Physiology, Water and Electrolytes Research Center, Kidney Diseases Research Center, Isfahan, Iran

3 Department of pediatrics, Isfahan Kidney Diseases Research Center, Isfahan Child Growth and Development Research Center, Isfahan University of medical sciences, Isfahan, Iran

4 Department of Urology, Isfahan Urology and Kidney Transplantation Research Centre, Isfahan, Iran


Background: Renal maldevelopment, interstitial fibrosis, ischemic atrophy, decreased glomerular filtration rate (GFR), and renal blood flow (RBF) are inevitable consequences of chronic kidney obstruction that only partially improve after early intervention. There are only few studies that evaluated urine osmolality in affected kidney and its correlation with short-term outcome.
Materials and Methods: Thirty patients (age<1 year) with unilateral ureteropelvic junction obstruction (UUPJO) were enrolled in this study. UUPJO was confirmed using Technetium 99 isotope scans and the patients were indicated to be operated afterward. Urine and blood samples were obtained before, 24, 48, and 72 h after the surgery. The serum level of blood urea nitrogen, creatinine, and glucose were measured. GFR, urine osmolality (measured and calculated), and urine specific gravity were determined too.
Results: Cortical thickness of hydronephrotic kidney was significantly increased 6 months after the surgery. GFR was significantly increased 72-h postsurgery compared to before operation.
Neither means of calculated nor of measured urine osmolalities were significantly different in various stages. The last calculated urine osmolality (72 h) had significant correlation with the last measured osmolality (72 h); r0=0.962, P=0.0001. The last GFR (72 h) had positive significant correlation with GFR before the surgery and GFRs at 24 and 48 h postsurgery.
Using regression tests, only the before surgery GFR was the predictor of the last GFR(72 h).
Conclusion: In UUPJO the measured and calculated urine osmolality of the affected kidney did not differ.
In addition, GFR before surgery should be considered as the predictor of the GFR shortly after repair.


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