Ultrasonography in distinguishing optic neuritis from nonarteritic anterior ischemic optic neuropathy

Dehghani, Alireza; Giti, Masoomeh; Akhlaghi, Mohamad Reza; Karami, Mehdi; Salehi, Fatemeh

Ultrasonography in distinguishing optic neuritis from nonarteritic anterior ischemic optic neuropathy

Authors

¹ Department of Ophthalmology, Isfahan Eye Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

² Department of Radiology, Tehran University of Medical Sciences, Tehran, Iran

³ Deparment of Radiology, Isfahan University of Medical Sciences, Isfahan, Iran

⁴ Medical Students Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

Abstract

Background and Objectives: Optic neuritis (ON) and nonarteritic anterior ischemic optic neuropathy (NAION) have some overlapping clinical profiles. We evaluated the usefulness of B-scan ultrasonography in distinguishing ON from NAION by measuring diameter of the optic nerve.
Materials and Methods: Consecutive patients with an acute noncompressive unilateral optic neuropathy with relative afferent pupillary defect and onset of visual loss during the last 2 weeks were included. Diagnosis of ON was based on age ≤ 35 years, orbital pain associated with eye movement, and no disk edema, and diagnosis of NAION was based on age ≥ 60 years, no orbital pain associated with eye movement, and presence of disk edema. Age- and gender-matched subjects without ocular disease were selected for comparison. The diameter of the optic nerve was measured by a single radiologist with B-scan ultrasonography.
Results: In ON patients, the mean diameter of the affected nerve was significantly larger than that of the unaffected nerve and also larger than that of the right nerve of young controls; P < 0.05. In NAION patients, however, there was no significant difference between the mean diameter of the affected nerve and of the unaffected nerve or the right nerve of elderly controls; P > 0.05. Also, the diameter of the affected nerve was significantly larger in ON than in AION patients; P < 0.05.
Conclusion: B-scan ultrasonography is helpful in the early stages of optic neuropathy to distinguish ON from NAION in those cases for which the diagnosis is still uncertain after clinical evaluation.

Keywords

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