Assessment of relationship between active ulcerative colitis and cytomegalovirus infection among Iranian patients

Authors
Mojgan Mokhtari 1
Hamid Tavakkoli 2
Azita Rafiee 3
Ramin Dibaj 1
1 Department of Pathology, Isfahan University of Medical Science, Isfahan, Iran
2 Department of Gastroenterology, Isfahan University of Medical Science, Isfahan, Iran
3 Master Science of Medical Microbiology, Infectious and Tropical Diseases Research Center, Isfahan University of Medical Science, Isfahan, Iran
Abstract
Introduction: It has been previously reported that ulcerative colitis (UC) could be associated with cytomegalovirus (CMV) infection. There is controversy among different studies; however, this study is conducted in Isfahan. We evaluated the frequency distribution of CMV infection in Iranian patients with active UC comparison to normal individuals.
Materials and Methods: This case-control study was conducted on 22 patients with active UC and 22 age- and sex-matched controls (F: M = 1). Samples were taken from colonoscopic specimens and tested with sensitive primers of the CMV using the polymerase chain reaction method, the most sensitive method for detecting CMV infection.
Results: Patients and controls were similar in age (35.9 ± 11.03 years in the case and 40.8 ± 11.3 years in the control group) P=0.153. CMV DNA was found in 13.6% of the subjects in each group; therefore, total percentage of CMV infection was 13.6%. Six cases with CMV infection were three males and three females with age of 38.5 ± 11.02 years (compared to 38.3 ± 11.5 years in noninfected subjects P=0.968).
Conclusion: In our study, Iranian patients with active UC did not have a higher rate of CMV infection than controls.

Keywords

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Advanced Biomedical Research
Volume 2012, July
July 2012
Pages 1-3