Wegener`s granulomatosis and mucoromycosis: A case study and review of literature

Authors

1 Department of Otorhinolaryngology, Kashani Hospital, Isfahan University of Medical Science, Isfahan, Iran

2 Department of Otorhinolaryngology, Isfahan University of Medical Science, Isfahan, Iran

3 Department of Rheumatology, Isfahan University of Medical Science, Isfahan, Iran

4 Isfahan Faculty Of Medicine, Isfahan University of Medical Science, Isfahan, Iran

5 Department of Pathology, Alzahra hospital, Isfahan University of Medical Science, Isfahan, Iran

Abstract

Mucormycosis is a fatal invasive infection which mostly involves diabetic or immunosuppressed patients. Early diagnosis, improving immunosuppression, systemic antifungal therapy, and surgical debridement are necessary for successful treatment. In this case study, we represent a known case of Wegener's granulomatosis (WG), with concomitant sinusal mucormycosis mimicking vasculitic disease relapse, which was successfully treated with surgical debridement, amphotericine, and intravenous immunoglobuline.

Keywords

1. Watts R, Lane S, Hanslik T, Hauser T, Hellmich B, Koldingsnes W, et al. Development and validation of a consensus methodology for the classification of the ANCA-associated vasculitides and polyarteritis nodosa for epidemiological studies. Ann Rheum Dis. 2007;66:222.  Back to cited text no. 1
[PUBMED]  [FULLTEXT]  
2. Leavitt RY, Fauci AS, Bloch DA, Michel BA, Hunder GG, Arend WP, et al. Jr The American College of Rheumatology 1990 criteria for the classification of Wegener's granulomatosis. Arthritis Rheum. 1990;33:1101.  Back to cited text no. 2
[PUBMED]    
3. Adu D, Pall A, Luqmani RA, Richards NT, Howie AJ, Emery P, et al. Controlled trial of pulse versus continuous prednisolone and cyclophosphamide in the treatment of systemic vasculitis. QJM. 1997;90:401.  Back to cited text no. 3
[PUBMED]  [FULLTEXT]  
4. Nogueira EL, Ind PW, Friedland JS, Salama AD. Mucormycosis may mimic disease relapse in Wegener's granulomatosis. J Rheumatol. 2010 Jun;37:1364-5.  Back to cited text no. 4
    
5. Berenguer J, Solera J, Moreno S, Muñoz P, Parras F. [Mucormycosis. The disease spectrum in 13 patients] Med Clin (Barc). 1990 May 26;94:766-72.   Back to cited text no. 5
    
6. Seo P, Stone JH. The antineutrophil cytoplasmic antibody-associated vasculitides. Am J Med. 2004;117:39.  Back to cited text no. 6
[PUBMED]  [FULLTEXT]  
7. Ferguson BJ. fungal rhinisinosits. In: Flint WP, Haughey BH, Lund VJ, Niparko JK, Richardson MA, Robbins KT, and Thomas JR. Cummings Otolaryngology - Head and Neck Surgery, 5 th Edition, volume 1,China,Mosby Elsevier,2010; p708-16.  Back to cited text no. 7
    
8. Jayne DR, Chapel H, Adu D, Misbah S, O'Donoghue D, Scott D, Lockwood CM.Intravenous immunoglobulin for ANCA-associated systemic vasculitis with persistent disease activity. QJM. 2000;93:433.  Back to cited text no. 8
[PUBMED]  [FULLTEXT]