Galactomannan antigen assay from bronchoalveolar lavage fluid in diagnosis of invasive pulmonary aspergillosis in intensive care units patients

Authors
Farzin Khorvash 1
Mohsen Meidani 2
Leila Babaei 3
Saeed Abbasi 4
Behrooz Ataei 2
Majid Yaran 2
1 Department of Infectious Diseases, Nosocomial Infection Research center, Isfahan University of Medical Sciences, Isfahan, Iran
2 Department of Infectious Diseases, Infectious Diseases and Tropical Medicine Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
3 School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
4 Department of Anesthesiology, Isfahan University of Medical Sciences, Isfahan, Iran
Abstract
Background : Invasive pulmonary aspergillosis (IPA) is an important infection in critically ill patients including patients of intensive care units (ICU). Different diagnostic tools are available and since its mortality is high, it is vital to start the antifungal therapy as soon as possible. Knowing the epidemiology of this disease in each ICU and area will help to better and more rapid management of such patients. The aim of this study is to determine the frequency of IPA based on the level of galactomannan in bronchoalveolar lavage fluid in ICU of Al-Zahra hospital, Isfahan, Iran.
Materials and Methods : This was a cross sectional study, which was conducted in Al-Zahra hospital, Isfahan, Iran, between 2010 to 2011. The study population was all the patients admitted to ICU and were suspected to have invasive Aspergillus spp pneumonia. The level of galactomannan in bronchoalveolar lavage was measured and demographic data were gathered by the questionnaire.
Results : The frequency of IPA in this study was calculated as 2.43% while galactomannan level in bronchoalveolar lavage fluid of this patient (2.50) was significantly higher than others (0.03 ± 0.02).
Conclusion : Larger studies are required to determine the exact frequency of IPA and the best antifungal therapy for it.

Keywords

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Advanced Biomedical Research
Volume 2014, January
January 2014
Pages 1-5