Advanced Biomedical Research

Prevalence and risk factors of hepatitis B and C viruses among hemodialysis patients in Isfahan, Iran

Authors

1 Department of Gastroenterology, Isfahan Liver Disease Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

2 Department of Internal Medicine, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

3 Department of Infectious Diseases, Infectious Diseases and Tropical Medicine Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

4 Department of Epidemiology and Biostatistics, School of Public Health, Isfahan University of Medical Sciences, Isfahan, Iran

5 Department of Obstetrics and Gynecology, Isfahan University of Medical Sciences, Isfahan, Iran

Abstract

Background: The aim of this study was to assess the prevalence of hepatitis B virus (HBV) and hepatitis C virus (HCV) and their associated risk factors among hemodialysis patients in Isfahan, Iran in 2011.
Materials and Methods : In this cross-sectional study, a total of 499 chronic hemodialysis patients from eight governmental hemodialysis centers were tested. Demographic information, time duration on hemodialysis, history of blood transfusion, and the number of transfused blood units as risk factors to HBV and HCV infections were calculated. The status of HBsAg and anti-HCV was assessed by serological testing.
Results: The overall prevalence of HBV-positive and HCV-positive among study population was 1.2% and 5.2%, respectively. Age, sex, and time duration on hemodialysis were not statistically significant in HBV- and HCV-patients compared with other hemodialysis patients (P0 > 0.05). History of blood transfusion and the number of transfused blood units in HBV infected patients were similar to other patients (P > 0.05). The main risk factors in hemodialysis patients infected by HCV were history of blood transfusion and the number of transfused blood units (P < 0.0001).
Conclusion: In conclusion, the prevalence of HBV and HCV infections in hemodialysis centers in Isfahan is lower than in some other cities of Iran. History of blood transfusion and the number of blood units transfused might be a risk factor for HCV gaining. However, further studies are needed to assess the role of other demographic and clinical risk factors in these patients.

Keywords

1. Santos MG, Danguilan RA, Que ET, Balmaceda RP, Padilla BS. Prevalence of hepatitis B and hepatitis C in hemodialysis patients. Nephrology 1998;4:101-4.  Back to cited text no. 1
    
2. Zahedi MJ, Darvish Moghaddam S, Alavian SM, Dalili M. Seroprevalence of Hepatitis Viruses B, C, D and HIV Infection Among Hemodialysis Patients in Kerman Province, South-East Iran. Hepat Mon 2012;12:339-43.  Back to cited text no. 2
[PUBMED]    
3. Hinrichsen H, Leimenstoll G, Stegen G, Schrader H, Fölsch UR, Schmidt WE. PHV Study Group. Prevalence and risk factors of hepatitis C virus infection in haemodialysis patients: A multicentre study in 2796 patients. Gut 2002;51:429-33.  Back to cited text no. 3
    
4. Arababadi MK, Hassanshahi G, Yousefi H. HBV-DNA in hemodialysis patients infected by HCV. Saudi J Kidney Dis Transpl 2009;20:398-401.  Back to cited text no. 4
[PUBMED]  Medknow Journal  
5. Lopez-Alcorocho JM, Barril G, Ortiz-Movilla N, Traver JA, Bartolomé J, Sanz P, et al. Prevalance of hepatitis B, hepatitis C, GB virus C/hepatitis G and TT viruses in hemodialysis patients. J Med Virol 2001;63:103-7.  Back to cited text no. 5
    
6. Jafarzadeh A, Kazemi Arababadi M, Mirzaee M, Pourazar A. Occult hepatitis B virus infec-tion among blood donors with antibodies to hepatitis B core antigen. Acta Med Iran 2008;46:27-32.  Back to cited text no. 6
    
7. Chan HL, Tsang SW, Leung NW, Tse CH, Hui Y, Tam JS, et al. Occult HBV infection in cryptogenic liver cirrhosis in an area with high prevalence of HBV infection. Am J Gastroenterol 2002;97:1211-5.  Back to cited text no. 7
[PUBMED]    
8. Carpenter PA, Huang ML, McDonald GB. Activation of occult hepatitis B from seronega-tive patient after hematopoietic cell transplant: A cautionary tale. Blood 2002;99:4245-6.  Back to cited text no. 8
[PUBMED]    
9. Naman RE, Mansour I, Klayme S, Khalil G. Hepatitis C virus in hemodialysis patients and blood donors in Lebanon. J Med Liban 1996;44:4-9.  Back to cited text no. 9
[PUBMED]    
10. Bdour S. Hepatitis C virus infection in Jordanian haemodialysis units: Serological diagnosis and genotyping. J Med Microbiol 2002;51:700-4.  Back to cited text no. 10
[PUBMED]    
11. Othman B, Monem F. Prevalence of antibodies to hepatitis C virus among hemodialysis patients in Damascus, Syria. Infection 2001;29:262-5.  Back to cited text no. 11
[PUBMED]    
12. Abdulkarim AS, Zein NN, Germer JJ, Kolbert CP, Kabbani L, Krajnik KL, et al. Hepatitis C virus genotype and hepatitis G virus in hemodialysis patients from Syria: Identification of two novel hepatitis C virus subtypes. Am J Trop Med Hyg 1998;59:571-6.  Back to cited text no. 12
[PUBMED]    
13. Fissell RB, Bragg-Gresham JL, Woods JD, Jadoul M, Gillespie B, Hedderwick SA, et al. Patterns of hepatitis C prevalence and seroconversion in hemodialysis units from three continents: The DOPPS. Kidney Int 2004;65:2335-42.  Back to cited text no. 13
[PUBMED]    
14. Johnson DW, Dent H, Yao Q, Tranaeus A, Huang CC, Han DS, et al. Freauencies of hepatitis B and infections among haemodialysis and peritoneal dialysis patients in Asia-Pacific countries: Analysis of registry data. Nephrol Dial Transplant 2009;24:1598-603.  Back to cited text no. 14
[PUBMED]    
15. Mioli VA, Balestra E, Bibiano L, Carletti P, Della Bella S, Fanciulli E, et al. Epidemiology of viral hepatitis in dialysis centers: A national survey. Nephron 1992;61:278-83.  Back to cited text no. 15
[PUBMED]    
16. Fabrizi F, Martin P, Dixit V, Bunnapradist S, Dulai G. Hepatitis C virus antibody status and survival after renal transplantation: Meta-analysis of observational studies. Am J Transplant 2005;5:1452-61.  Back to cited text no. 16
[PUBMED]    
17. Irish DN, Blake C, Christophers J, Craske JE, Burnapp L, Abbs IC, et al. Identification of hepatitis C seroconversion resulting from nosocomial transmission on a haemodialysis unit: Implications for infection control and laboratory screening. J Med Virol 1999;59:135-40.  Back to cited text no. 17
[PUBMED]    
18. Katsoulidou A, Paraskevis D, Kalapothaki V, Arvanitis D, Karayiannis P, Hadjiconstantiou V, et al. Molecular epidemiology of a hepatitis C outbreak in a haemodialysis unit. Multicentre haemodialysis cohort study on viral hepatitis. Nephrol Dial Transplant 1999;14:1188-94.  Back to cited text no. 18
[PUBMED]    
19. Alavian SM, Einollahi B, Hajarizadeh B, Bakhtiari S, Nafar M, Ahrabi S. Prevalence of hepatitis C virus infection and related risk factors among Iranian haemodialysis patients. Nephrology (Carlton) 2003;8:256-60.  Back to cited text no. 19
[PUBMED]    
20. Joukar F, Besharati S, Mirpour H, Mansour-Ghanaei F. Hepatitis C and hepatitis B seroprevalence and associated risk factors in hemodialysis patients in Guilan province, north of Iran: HCV and HBV seroprevalence in hemodialysis patients. Hepat Mon 2011;11:178-81.  Back to cited text no. 20
[PUBMED]    
21. Assarehzadegan MA, Shakerinejad G, Noroozkohnejad R, Amini A, Rahim Rezaee SA. Prevalence of hepatitis C and B infection and HC V genotypes among hemodialysis patients in Khuzestan province, southwest Iran. Saudi J Kidney Dis Transpl 2009;20:681-4.  Back to cited text no. 21
[PUBMED]  Medknow Journal  
22. Alavian SM, Kabir A, Ahmadi AB, Lankarani KB, Shahbabaie MA, Ahmadzad-Asl M. Hepatitis C infection in hemodialysis patients in Iran: A systematic review. Hemodial Int 2010;14:253-62.  Back to cited text no. 22
[PUBMED]    
23. Merat S, Rezvan H, Nouraie M, Jamali A, Assari S, Abolghasemi H, et al. The prevalence of hepatitis B surface antigen and anti-hepatitis B core antibody in Iran: A population-based study. Arch Iran Med 2009;12:225-31.  Back to cited text no. 23
[PUBMED]    
24. El-kader Y El-Ottol A, Elmanama AA, Ayesh BM. Prevalence and risk factors of hepatitis B and C viruses among haemodialysis patients in Gaza strip, Palestine. Virol J 2010;7:210.  Back to cited text no. 24
[PUBMED]    
25. Covic A, Iancu L, Apetrei C, Scripcaru D, Volovat C, Mititiuc I, et al. Hepatits virus infection in haemodialysis patients from Moldavia. Nephrol Dial Transplant 1999;14:40-5.  Back to cited text no. 25
[PUBMED]    
26. Al Hijazat M, Ajlouni Y. Hepatitis B infection among patients receiving chronic hemodialysis at the Royal Medical Services in Jordan. Saudi J Kidney Dis Transpl 2008;19:260-7.  Back to cited text no. 26
    
27. Silva LK, Silva MB, Rodart IF, Lopes GB, Costa FQ, Melo ME, et al. Prevalence of hepatitis C virus (HCV) infection and HCV genotypes of hemodialysis patients in Salvador, Northeastern Brazil. Braz J Med Biol Res 2006;39:595-602.  Back to cited text no. 27
[PUBMED]    
28. de Medina M, Ashby M, Schlüter V, Hill M, Leclerq B, Pennell JP, et al. Prevalence of hepatitis C and G virus infection in chronic hemidialysis patients. Am J Kidney Dis 1998;31:224-6.  Back to cited text no. 28
Advanced Biomedical Research
Volume 2014, January
January 2014
Pages 1-5