Large ovarian leiomyoma in young woman

Authors
Parvin Rajabi 1
Mohsen Hani 1
Marzie Bagheri 1
Farnoosh Mirzadeh 2
1 Department of Pathology, Isfahan University of Medical Sciences, Isfahan, Iran
2 Department of Infectious Disease and Tropical Medicine, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
Abstract
Leiomyoma is benign mesenchymal tumor, that frequently occur in uterus but it rarely happens in ovary. Ovarian leiomyomas are seen concomitantly with uterine leiomyoma in about 78% of cases. They often discover incidentally but their most clinical manifestations are abdominal pain and palpable mass. Herein, we reported a large ovarian leiomyoma in a 22-year-old woman with abdominal pain and palpable mass at lower abdominal region. Computed tomography scan revealed large adnexal mass. Microscopic appearance was typical for leiomyoma but because its rarity in ovary the immunohistochemical staining was done. Major differential diagnostic considerations for this tumor in ovary are fibroma/thecoma, sclerosing stromal tumor, and leiomyosarcoma. The immunohistochemical staining with desmin, inhibin, and α-smooth muscle actin are helpful to rule out this differential diagnosis.

Keywords

1. Tomas D, Lenicek T, Tuckar N, Puljiz Z, Ledinsky M, Kruslin B. Primary ovarian leiomyoma associated with endometriotic cyst presenting with symptoms of acute appendicitis: A case report. Diagn Pathol 2009;4:25.  Back to cited text no. 1
    
2. Lim SC, Jeon HJ. Bilateral primary ovarian leiomyoma in a young woman: Case report and literature review. Gynecol Oncol 2004;95:733-5.  Back to cited text no. 2
    
3. Kurai M, Shiozawa T, Noguchi H, Konishi I. Leiomyoma of the ovary presenting with Meigs' syndrome. J Obstet Gynaecol Res 2005;31:257-62.  Back to cited text no. 3
    
4. Khaffaf N, Khaffaf H, Wuketich S. Giant ovarian leiomyoma as a rare cause of acute abdomen and hydronephrosis. Obstet Gynecol 1996;87:872-3.  Back to cited text no. 4
    
5. Usta U, Karadag N, TÜrkmen E, Haltas H . Primary leiomyoma of the ovary. Balkan Med J . 2006;23:39-42.  Back to cited text no. 5
    
6. Takeuchi S. A case report of laparoscopic resection of a large leiomyoma of the ovary that required an operation time of seven hours. J Rural Med 2009;4:35-7.  Back to cited text no. 6
    
7. Van Winter JT, Stanhope CR. Giant ovarian leiomyoma associated with ascites and polymyositis. Obstet Gynecol 1992;80:560-3.  Back to cited text no. 7
    
8. Tsalacopoulos G, Tiltman AJ. Leiomyoma of the ovary. A report of 3 cases. S Afr Med J 1981;59:574-5.  Back to cited text no. 8
[PUBMED]    
9. Koo YJ, Cho YJ, Kim JY, Lee JE, Kim ML, Kim JM, et al. Ovarian leiomyoma as a potential cause of compromised fertility. Fertil Steril 2011;95:1120.  Back to cited text no. 9
    
10. Ozcimen EE, Oktem M, Zeyneloglu HB, Ozdemir BH, Kuscu E. Primary leiomyoma of the ovary in a young woman: Literature review and report of a case. Eur J Gynaecol Oncol 2006;27:310-2.  Back to cited text no. 10
    
11. Yumru AE, Bozkurt M, Ayanoðlu YT, Ayhan I, Inci Coºkun E, Battal Havane S. The relation between the presence of a giant primary ovarian leiomyoma and the occurrence of epilepsy as a paraneoplastic syndrome. Arch Gynecol Obstet 2010;281:531-4.  Back to cited text no. 11
    
12. Güney M, Ozsoy M, Oral B, Mungan T, Kapucuoðlu N. Unilateral primary ovarian leiomyoma in adolescent: A case report. Arch Gynecol Obstet 2007;275:507-10.  Back to cited text no. 12
Advanced Biomedical Research
Volume 2014, February
February 2014
Pages 1-3