Should variation of serum lipid levels be considered a risk factor for the development of basal cell carcinoma?

Zamanian, Abbas; Rokni, Ghasem Rahmatpour; Ansar, Akram; Mobasher, Pezhman; Ahmadi Jazi, Ghazaleh

Should variation of serum lipid levels be considered a risk factor for the development of basal cell carcinoma?

Authors

¹ Skin and Stem Cell Research Center, Department of Dermatology; Department of Dermatology, Rasoul-e Akram Hospital, Iran University of Medical Sciences, Tehran, Iran

² Department of Dermatology, Hamedan University of Medical Sciences, Hamedan, Iran

³ Skin Diseases and Leishmaniasis Research Center, Department of Dermatology, Isfahan University of Medical Sciences, Isfahan; Skin and Stem Cell Research Center, Department of Dermatology, Tehran University of Medical Sciences, Tehran, Iran

⁴ Medical Ethics and History of Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran

Abstract

Background: Basal cell carcinoma (BCC) is the most common cutaneous neoplasm in human beings. Ultraviolet radiation is one of the most important predisposing factors for BCC. Although some recent investigations have shown a high serum level of phospholipids in actinic keratosis and BCC, this subject is still debated and needs approval. This study aimed to evaluate the association between serum lipid level and development of cutaneous BCC.
Materials and Methods: In this case-control study, lipid profile including triglyceride (TG), Cholesterol (CHOL), high-density lipoprotein (HDL) and low-density lipoprotein (LDL) were measured in 30 patients with BCC and 30 healthy controls. Data were analyzed by descriptive statistical tests including t tests and Chi square test.
Results: This study shows that the mean age of the case and control groups were 63.93 ± 12.09 and 61.57 ± 21.1 years (mean ± SD), respectively. The average amount of triglyceride, cholesterol, HDL and LDL in the BCC patients were 139.73 ± 69.11 mg/dl, 179.20 ± 43.42 mg/dl, 39.40 ± 9.30 mg/dl and 110.70 ± 34.13 mg/dl, respectively, whereas these amounts in the control group were 141.83 ± 80.41 mg/dl, 173.60 ± 96.32 mg/dl, 36.97 ± 6.35 mg/dl, 110.70 ± 34.13 mg/dl and 104.87 ± 30.85 mg/dl, respectively. No significant difference was found in the lipid profile of the case and control groups (P > 0.05%).
Conclusion: This study shows that the serum lipid levels in patients with BCC has no significant difference in comparison with the control group and, therefore, relevance between BCC and serum lipid level is not proven. Further studies with a larger sample size are necessary for evaluating this subject.

Keywords

References

1.	Ishioka P, Marques SA, Hirai AT, Marques ME, Hirata SH, Yamada S. Prevalence of precancerous skin lesions and non-melanoma skin cancer in Japanese-Braziliansin Bauru, São Paulo State, Brazil. Cad Saude Publica 2009;25:965-71.
2.	Bakos RM, Kriz M, Mühlstädt M, Kunte C, Ruzicka T, Berking C. Risk factors for early-onset basal cell carcinoma in a German institution. Eur J Dermatol 2011;21:705-9.
3.	Dessinioti C, Tzannis K, Sypsa V, Nikolaou V, Kypreou K, Antoniou C, et al. Epidemiologic risk factors of basal cell carcinoma development and ageat onset in a Southern European population from Greece. Exp Dermatol 2011;20:622-6.
4.	Ollstein RN. Skin lesions in the elderly: Precancer and cancer. Care Manag J 2004;5:107-11.
5.	Saladi RN, PersaudAN.The causes of skin cancer: A comprehensive review. Drugs Today (Barc) 2005;41:37-53.
6.	Crowson AN. Basal cell carcinoma: Biology, morphology and clinical implications. Mod Pathol 2006;19(Suppl 2):S127-47.
7.	Patel PS, Shah MH, Jha FP, Raval GN, Rawal RM, Patel MM, et al. Alterations in plasma lipid profile patterns in head and neck cancer and oralprecancerous conditions. Indian J Cancer 2004;41:25-31. [PUBMED]
8.	Ibiebele TI, van der Pols JC, Hughes MC, Marks GC, Williams GM, Green AC. Dietary pattern in association with squamous cell carcinoma of the skin: A prospective study. Am J Clin Nutr 2007;85:1401-8.
9.	Chawda JG, Jain SS, Patel HR, Chaduvula N, Patel K. The relationship between serum lipid levels and the risk of oral cancer.Indian J Med Paediatr Oncol 2011;32:34-7. [PUBMED]
10.	Vural P, Canbaz M, Sekçuki D, Murat A. Lipid profile in actinic keratosis and basal cell carcinoma. Int J Dermatol 1999;38:439-42.
11.	Raste AS, NaikPP. Clinical significance of lipid profile in cancer patients. Indian J Med Sci 2000;54:435-41. [PUBMED]
12.	McIntosh LM, Jackson M, Mantsch HH, Stranc MF, Pilavdzic D, Crowson AN. Infrared spectra of basal cell carcinomas are distinct from non-tumor-bearing skin components. J Invest Dermatol 1999;112:951-6.
13.	Vural P, CanbazM, Selçuki D. Plasma antioxidant defense in actinic keratosis andbasal cell carcinoma. J Eur Acad Dermatol Venereol 1999;13:96-101.
14.	Heinen MM, Hughes MC, Ibiebele TI, Marks GC, Green AC, van der Pols JC. Intake of antioxidant nutrients and the risk of skin cancer. Eur J Cancer 2007;43:2707-16.
15.	van DamRM, Huang Z, Giovannucci E, Rimm EB, Hunter DJ, Colditz GA, et al. Diet and basal cell carcinoma of the skin in a prospective cohort ofmen. Am J Clin Nutr 2000;71:135-41.
16.	Hunter DJ, Colditz GA, Stampfer MJ, Rosner B, Willett WC, Speizer FE.Diet and risk of basal cell carcinoma of the skin in a prospective cohort of women. Ann Epidemiol 1992;2:231-9.

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