Advanced Biomedical Research

Myeloperoxidase levels predicts angiographic severity of coronary artery disease in patients with chronic stable angina

Authors

1 Isfahan Cardiovascular Research Center, Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran

2 Department of Biostatistics, Isfahan University of Medical Sciences, Isfahan, Iran

3 Environment Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

4 Cardiac Rehabilitation Research Center, Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran

Abstract

Background : Myeloperoxidase (MPO) has an important role in the both processes of inflammation and oxidative stress. It plays proatherogenic role via low-density lipoprotein oxidation, functional inactivation of the high-density lipoprotein and endothelial dysfunction, and seems to be involved in the atherogenesis of coronary arteries. This study designed to evaluate the association between the plasma MPO levels and angiographic severity of coronary artery disease (CAD) in patients with the stable CAD.
Materials and Methods: Sixty-eight patients who had documented CAD with angiography and 66 subjects who had normal angiography were selected as case and the control groups for this study, respectively. Gensini scoring system was used for evaluation of severity of coronary artery stenosis. Plasma MPO and C-reactiveprotein (CRP) levels of both case and control groups were determined.
Results: Plasma MPO levels and CRP levels were significantly higher in CAD patients (P < 0.001), and plasma levels of MPO and CRP were correlated with Genssini scores.
Conclusions: Our findings indicated that the plasma MPO levels increase in patients with stable CAD and hence that, it can be used as adiagnostic factor to predict the coronary artery atherosclerosis severity in stable CAD patients; However, it needs further widespread investigations to achieve an accurate cut point.

Keywords

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Advanced Biomedical Research
Volume 2014, june
June 2014
Pages 1-5