Design, formulation and evaluation of green tea chewing gum

Authors

1 Department of Pharmaceutics, School of Pharmacy and Novel Drug Delivery Systems Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

2 Department of Pharmacognosy, School of Pharmacy and Isfahan Pharmaceutical Sciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

Abstract

Background: The main purpose of this study is to design, formulate and evaluate the green tea gums with a suitable taste and quality in order to produce an anti-oxidant chewing gum.
Materials and Methods: Fresh green tea leaves obtained from Northern Iran for extraction. Maceration is the extraction method that is used in this study. The contents of caffeine, catechin and flavonoids of the hydro alcoholic extract were measured. Various formulations of the 120 mg green tea extract chewing gums with different sweeteners, flavoring agents and various gum bases were prepared afterward release pattern, content uniformity, organoleptic results and other properties were characterized.
Results: The contents of caffeine, catechin and flavonoid of the hydro alcoholic extraction were 207.32 mg/g, 130.00 mg/g and 200.82 mg/g, respectively. Release pattern of green tea chewing gum with different gum base ratios and various sweeteners in phosphate buffer were prepared. A total of 60 persons who were 20-30 years of age, participated in our panel test for organoleptic properties such as taste, stiffness, stickiness, etc., Acceptable gum was the one with the same ratio of the used rubber bases. Cinnamon selected as the preferred taste by volunteers. Combination of aspartame, sugar and maltitol has appropriate taste. The effect of various sweetener on release pattern was negligible, on the other hand rubber bases ratio variation, changed the release pattern obviously.
Conclusion: The green tea chewing gum with sugar, maltitol and aspartame sweeteners and cinnamon flavor, using the same rubber bases ratio may be a desirable antioxidant product.

Keywords

1. Landau JM, Lambert JD, Yang CS. Green tea. Nutritional Oncology. 2 nd ed. Burlington, Ma: Academic Press; 2006.  Back to cited text no. 1
    
2. Rahman K. Studies on free radicals, antioxidants, and co-factors. Clin Interv Aging 2007;2:219-36.  Back to cited text no. 2
    
3. Rosengren RJ. Utility of epigallocatechin gallate in the treatment and prevention of breast cancer: molecular mechanisms for tumor suppression. Handbook of Green Tea and Health Research, Eds: McKinley H and Jamieson M; 2009.  Back to cited text no. 3
    
4. Sharangi AB. Medicinal and therapeutic potentialities of tea (Camellia sinensis L.) - A review. Food Res Int 2009;42:529-35.  Back to cited text no. 4
    
5. Egashira N, Mishima K, Iwasaki K, Oishi R, Fujiwara M. Neuroprotective effect of theanine on cerebral ischemia. Handbook of Green Tea and Health Research, Eds: McKinley H and Jamieson M; 2009.  Back to cited text no. 5
    
6. Aslani A, Ghannadi A, Najafi H. Design, formulation and evaluation of a mucoadhesive gel from Quercus brantii L. and Coriandrum sativum L. as periodontal drug delivery. Adv Biomed Res 2013;2:21.  Back to cited text no. 6
    
7. Furuse M, Adachi N, Tomonaga S, Yamane H, Denbow DM. Central functions of green tea components. Handbook of Green Tea and Health Research, Eds: McKinley H and Jamieson M; 2009.  Back to cited text no. 7
    
8. Yun CH, Kim GR, Seo MJ, Moon HS, Cho CS. Anti-obesity effects of (-)-epigallocathchin 3-gallate and its molecular mechanism. Handbook of Green Tea and Health Research, Eds: McKinley H and Jamieson M; 2009.  Back to cited text no. 8
    
9. Golding JF. Motion sickness susceptibility. Auton Neurosci 2006;129:67-76.  Back to cited text no. 9
    
10. Allen AP, Smith AP. A review of the evidence that chewing gum affects stress, alertness and cognition. J Behav Neurosci Res 2011;9:7-23.  Back to cited text no. 10
    
11. Seibel K, Schaffler K, Reitmeir P, Golly I. A randomised, placebo-controlled study comparing two formulations of dimenhydrinate with respect to efficacy in motion sickness and sedation. Arzneimittelforschung 2002;52:529-36.  Back to cited text no. 11
    
12. Reiner A, Seneci A. Pharmaceutical compositions based on chewing gum and a method for the preparation thereof. US Patent 1998; [5,711,961].  Back to cited text no. 12
    
13. Johnson AJ, Miles C, Haddrell B, Harrison E, Osborne L, Wilson N, et al. The effect of chewing gum on physiological and self-rated measures of alertness and daytime sleepiness. Physiol Behav 2012;105:815-20.  Back to cited text no. 13
    
14. Miskewitz RM. Chewing gum product with dental health benefits. US Patent 1997; [5,693,334].  Back to cited text no. 14
    
15. Rassing MR. Chewing gum as a drug delivery system. Adv Drug Deliv Rev 1994;13:89-121.  Back to cited text no. 15
    
16. Deshpande A, Jadad AR. The impact of polyol-containing chewing gums on dental caries: A systematic review of original randomized controlled trials and observational studies. J Am Dent Assoc 2008;139:1602-14.  Back to cited text no. 16
    
17. Parrott AC, Winder G. Nicotine chewing gum (2 mg, 4 mg) and cigarette smoking: Comparative effects upon vigilance and heart rate. Psychopharmacology (Berl) 1989;97:257-61.  Back to cited text no. 17
    
18. William PV, Millind T. A comprehensive review on: medicated chewing gum. Int J Res Pharm Biomed Sci 2012;3:894-907.  Back to cited text no. 18
    
19. Ghannadi A, Hajhashemi V, Abrishami R. Effects of the Persian Carum copticum fruit extracts on morphine withdrawal syndrome in mice. Res Pharm Sci 2012;7:127-31.  Back to cited text no. 19
    
20. Eteng MU, Eyong EU, Eka OU, Umoh IB, Ebong PE, Ettarh RR. Caffeine and theobromine levels in selected Nigerian beverages. Plant Foods Hum Nutr 1999;54:337-44.  Back to cited text no. 20
    
21. Kivits G, Sman F, Tijburg L. Analysis of catechins from green and black tea in humans: a specific and sensitive colorimetric assay of total catechins in biological fluids. Int J Food Sci Nutr 1997;48:387-92.  Back to cited text no. 21
    
22. Chang CC, Yang MH, Wen HM, Chern JC. Estimation of total flavonoid content in propolis by two complementary colorimetric methods. J Food Drug Anal 2002;10:178-82.  Back to cited text no. 22
    
23. Costa P, Sousa Lobo JM. Modeling and comparison of dissolution profiles. Eur J Pharm Sci 2001;13:123-33.  Back to cited text no. 23
    
24. Mulder TP, Rietveld AG, van Amelsvoort JM. Consumption of both black tea and green tea results in an increase in the excretion of hippuric acid into urine. Am J Clin Nutr 2005;81:256S-60.  Back to cited text no. 24
    
25. Vuong QV, Golding JB, Nguyen MH, Roach PD. Preparation of decaffeinated and high caffeine powders from green tea. Powder Technol 2013;233:169-75.  Back to cited text no. 25
    
26. Ye JH, Liang YR, Jin J, Liang HL, Du YY, Lu JL, et al. Preparation of partially decaffeinated instant green tea. J Agric Food Chem 2007;55:3498-502.  Back to cited text no. 26
    
27. Chandra S, De Mejia Gonzalez E. Polyphenolic compounds, antioxidant capacity, and quinone reductase activity of an aqueous extract of Ardisia compressa in comparison to mate (Ilex paraguariensis) and green (Camellia sinensis) teas. J Agric Food Chem 2004;52:3583-9.  Back to cited text no. 27
    
28. Henning SM, Fajardo-Lira C, Lee HW, Youssefian AA, Go VL, Heber D. Catechin content of 18 teas and a green tea extract supplement correlates with the antioxidant capacity. Nutr Cancer 2003;45:226-35.  Back to cited text no. 28
    
29. Pelillo M, Biguzzi B, Bendini A, Toschi TG, Vanzini M, Lercker G. Preliminary investigation into development of HPLC with UV and MS-electrospray detection for the analysis of tea catechins. Food Chem 2002;78:369-74.  Back to cited text no. 29
    
30. Kim SY, Jeong SM, Jo SC, Lee SC. Application of far-infrared irradiation in the manufacturing process of green tea. J Agric Food Chem 2006;54:9943-7.  Back to cited text no. 30
    
31. Lee SC, Kim SY, Jeong SM, Park JH. Effect of far-infrared irradiation on catechins and nitrite scavenging activity of green tea. J Agric Food Chem 2006;54:399-403.  Back to cited text no. 31
    
32. Aslani A, Jalilian F. Design, formulation and evaluation of caffeine chewing gum. Adv Biomed Res 2013;2:72.  Back to cited text no. 32
[PUBMED]  Medknow Journal  
33. Tyrpin HT, Russell MP, Witkewitz DL, Johnson SS, Ream RL, Corriveau CL. Caffeine coated chewing gum product and process of making. US Patent 2002; [6,444,241].  Back to cited text no. 33
    
34. Aslani A, Rafiei S. Design, formulation and evaluation of nicotine chewing gum. Adv Biomed Res 2012;1:57.  Back to cited text no. 34
[PUBMED]  Medknow Journal  
35. Kvist C, Andersson SB, Fors S, Wennergren B, Berglund J. Apparatus for studying in vitro drug release from medicated chewing gums. Int J Pharm 1999;189:57-65.  Back to cited text no. 35
    
36. Kvist LC, Andersson SB, Berglund J, Wennergren B, Fors SM. Equipment for drug release testing of medicated chewing gums. J Pharm Biomed Anal 2000;22:405-11.  Back to cited text no. 36