Polycythemia, increased erythropoietin levels in a patient with renal lymphoma

Authors
Riyaz Ahmad Bhat 1
Imran Khan 1
Irfan Khan 2
Mohd Ashraf Mir 3
1 Department of General Medicine, Sher-i-Kashmir Institute of Medical Sciences, Soura, Srinagar, Kashmir, India
2 Department of Endocrinology, Sher-i-Kashmir Institute of Medical Sciences, Soura, Srinagar, Kashmir, India
3 Department of Pathology, Govt Medical College, Jammu, India
Abstract
A young male presented to our clinic with 3 months history of shortness of breathness and progressive distension of abdomen. On investigations, patient had renal failure, polycythemia and nephromegaly. A diagnosis of non-Hodgkin's lymphoma was made on renal and lymph node biopsy. Serum erythropoietin concentrations were physiologically inappropriate. - Erythropoietin immunohistochemistry on renal tissue samples demonstrated positive staining for tumor cells. This patient was managed as a case of infiltrative lymphoproliferative disorder with kidney involvement having polycythemia owing to paraneoplastic Erythropoietin production and possibly local hypoxia produced by tumor cells. With maximum efforts, we could not find such an association in the literature.

Keywords

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Advanced Biomedical Research
Volume 2014, june
June 2014
Pages 1-3