Analysis of gender based differences in auditory evoked potentials among healthy elderly population

Gupta, Sharat; Mittal, Shallu; Baweja, Pooja; Kumar, Avnish; Singh, Kamal Dev; Sharma, Raghuvansh

Analysis of gender based differences in auditory evoked potentials among healthy elderly population

Authors

¹ Department of Physiology, Gian Sagar Medical College, Patiala, Punjab, India

² Department of Physiology, Government Medical College, Patiala, Punjab, India

³ Department of Internal Medicine, Government Medical College, Patiala, Punjab, India

Abstract

Background: Influence of gender on auditory evoked potentials is contentious. Although there are quite a few studies documenting the gender as an influencing factor on auditory evoked potentials in younger subjects, but there is a lack of similar studies among elderly population. The present study was conducted to find out the pattern of gender based differences in auditory evoked potentials among healthy elderly subjects.
Materials and Methods: A cross-sectional study was conducted on age matched, healthy males (n = 35) and females (n = 34), aged 50-70 years. The measures included latencies of waves I-V and interpeak latencies (IPL) I-III, III-V and I-V separately for both ears. Data was analyzed statistically using Students unpaired t-test, using Statistical Package for Social Sciences software v13.0.
Results: The values of all the latencies and IPL for both the ears were non-significantly higher (P > 0.05) in males as compared to females. These results may be attributed to the differences in head circumference between both the genders and to the changed hormonal milieu of sex hormones after menopause.
Conclusions: Statistical insignificance of latencies among male and female elderly subjects excludes gender as an influencing factor on auditory evoked potentials in this age group.

Keywords

References

1.	Misra UK, Kalita J. Brain stem auditory evoked potential. In: Misra UK, Kalita J, editors. Clinical Neurophysiology. New Delhi: Elsevier Publications; 2006. p. 329-45.
2.	Biacabe B, Chevallier JM, Avan P, Bonfils P. Functional anatomy of auditory brainstem nuclei: Application to the anatomical basis of brainstem auditory evoked potentials. Auris Nasus Larynx 2001;28:85-94.
3.	Singh HJ, Sharma RS, Kaur S. The study of age and sex related changes in the brainstem auditory evoked potentials. J Clin Diagn Res 2010;4:3495-9.
4.	López-Escámez JA, Salguero G, Salinero J. Age and sex differences in latencies of waves I, III and V in auditory brainstem response of normal hearing subjects. Acta Otorhinolaryngol Belg 1999;53:109-15.
5.	Tafti FM, Gharib K, Teimuri H. Study of age effect on brainstem auditory evoked potential waveforms. J Med Sci 2007;7:1362-5.
6.	Tandon OP, Krishna SV. Brainstem auditory evoked potentials in children: A normative study. Indian Pediatr 1990;27:737-40.
7.	Tandon OP. Auditory brainstem evoked responses in healthy north Indians. Indian J Med Res 1990;92:252-6.
8.	Guideline 9C: Guidelines on short latency auditory evoked potentials. American Clinical Neurophysiological Society, 2008. Available from: http://www.acns.org/pdfs/Guideline%209C1.pdf. [Last Accessed on 2012 Dec 23].
9.	Rozkhov VP, Soroko SI. Age and sex related differences in brainstem auditory evoked potentials in secondary school children living in Northern European Russia. Human Physiol 2009;35:707-13.
10.	Lakshmi J, Susheela V, Krishnamurthy N, Madanmohan N, Taneja HC. Influence of gender on brainstem auditory evoked potentials. Biomedicine 2000;20:67-72.
11.	Solanki JD, Joshi N, Mehta HB, Shah CJ. A study of gender, head circumference and BMI as a variable affecting the BAEP results of late teenagers. Indian J Otol 2012;18:3-6.
12.	Ponton CW, Eggermont JJ, Coupland SG, Winkelaar R. The relation between head size and auditory brain-stem response interpeak latency maturation. J Acoust Soc Am 1993;94:2149-58.
13.	Dehan CP, Jerger J. Analysis of gender differences in the auditory brainstem response. Laryngoscope 1990;100:18-24.
14.	Metherate R. Functional connectivity and cholinergic modulation in auditory cortex. Neurosci Biobehav Rev 2011;35:2058-63.
15.	Schofield BR, Motts SD, Mellott JG. Cholinergic cells of the pontomesencephalic tegmentum: Connections with auditory structures from cochlear nucleus to cortex. Hear Res 2011;279:85-9.
16.	Caruso S, Cianci A, Grasso D, Agnello C, Galvani F, Maiolino L, et al. Auditory brainstem response in postmenopausal women treated with hormone replacement therapy: A pilot study. Menopause 2000;7:178-83.
17.	Khaliq F, Tandon OP, Goel N. Auditory evoked responses in postmenopausal women on hormone replacement therapy. Indian J Physiol Pharmacol 2003;47:393-9.

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