A brief study of toxic effects of some medicinal herbs on kidney

Author

Department of Pharmacy, GRD (PG) Institute of Management and Technology, Uttarakhand, India

Abstract

Increased use of complementary and alternative herbal medicines in the treatment of various diseases.Some herbal therapies may be causes of potential toxicity that may be renal toxicity caused by the ingestion of herbs. The goal of this study is the toxic and beneficial effects of medicinal herbs on renal health by which evidence for benefit or toxicity has been found. Included are nephrotoxicity from aristolochic acid and other components within herbs, herb-drug interactions, heavy metal toxicity in herbs and adulterants during careless preparation of herbal medicine, resulting in adverse renal effects and renal toxicity from contaminants within the extracts. The review aims to provide knowledge and guide to encourage future toxicity studies on the kidney by medicinal herbs.

Keywords

1. Lans CA. Ethnomedicines used in Trinidad and Tobago for urinary problems and diabetes mellitus. J EthnobiolEthnomed2006;2:45.  Back to cited text no. 1
[PUBMED]    
2. MacLennan AH, Wilson DH, Taylor AW. The escalating cost and prevalence of alternative medicine. Prev Med 2002;35:166-73.  Back to cited text no. 2
[PUBMED]    
3. Cheng S. Heavy metals in plants and phytoremediation. Environ SciPollut Res 2003;10:335-40.  Back to cited text no. 3
    
4. Cosyns JP, Jadoul M, Squifflet JP, Wese FX, van Ypersele de Strihou C. Urothelial lesions in Chinese-herb nephropathy. Am J Kidney Dis 1999;33:1011-7.  Back to cited text no. 4
[PUBMED]    
5. Gorey JD, Wahlqvist ML, Boyce NW. Adverse reaction to a Chinese herbal remedy. Med J Aust1992;157:484-6.  Back to cited text no. 5
[PUBMED]    
6. Hilepo JN, Bellucci AG, Mossey RT. Acute renal failure caused by 'cat's claw' herbal remedy in a patient with systemic lupus erythematosus. Nephron 1997;77:61.  Back to cited text no. 6
[PUBMED]    
7. Vanherweghem LJ. Misuse of herbal remedies: The case of an outbreak of terminal renal failure in Belgium (Chinese herbs nephropathy). J Altern Complement Med 1998;4:9-13.  Back to cited text no. 7
[PUBMED]    
8. Gillerot G, Jadoul M, Arlt VM, van Ypersele De Strihou C, Schmeiser HH, But PP, et al.Aristolochic acid nephropathy in a Chinese patient: Time to abandon the term 'Chinese herbs nephropathy'?. Am J Kidney Dis 2001;38:E26.  Back to cited text no. 8
[PUBMED]    
9. Solez K, Daugirdas J, Gregory MC, Frohnert PP, Bhowmik DM, Jha V, et al. Is 'Chinese herbs nephropathy' a prejudicial term?.Am J Kidney Dis 2001;38:1141-2.  Back to cited text no. 9
[PUBMED]    
10. Bieler CA, Stiborova M, Wiessler M, Cosyns JP, van Ypersele de Strihou C, Schmeiser HH. 32P-post-labelling analysis of DNA adducts formed by aristolochic acid in tissues from patients with Chinese herbs nephropathy. Carcinogenesis 1997;18:1063-7.  Back to cited text no. 10
    
11. Schmeiser HH, Bieler CA, Wiessler M, van Ypersele de Strihou C, Cosyns JP. Detection of DNA adducts formed by aristolochic acid in renal tissue from patients with Chinese herbs nephropathy. Cancer Res 1996;56:2025-8.  Back to cited text no. 11
[PUBMED]    
12. Ioset JR, Raoelison GE, Hostettmann K. Detection of aristolochic acid in Chinese phytomedicines and dietary supplements used as slimming regimens. Food ChemToxicol2003;41:29-36.  Back to cited text no. 12
[PUBMED]    
13. Tanaka A, Nishida R, Maeda K, Sugawara A, Kuwahara T. Chinese herb nephropathy in Japan presents adult-onset Fanconi's syndrome: Could different components of aristolochic acids cause a different type of Chinese herb nephropathy? ClinNephrol2000;53:301-6.  Back to cited text no. 13
[PUBMED]    
14. Nortier JL, Vanherweghem JL. Renal interstitial fibrosis and urothelial carcinoma associated with the use of a Chinese herb (Aristolochiafangchi). Toxicology 2002;181-2:577-80.  Back to cited text no. 14
    
15. Arlt VM, Pfohl-Leszkowicz A, Cosyns J, Schmeiser HH. Analyses of DNA adducts formed by ochratoxin A and aristolochic acid in patients with Chinese herbs nephropathy. Mutat Res 2001;494:143-50.  Back to cited text no. 15
[PUBMED]    
16. Jorgensen K. Survey of pork, poultry, coffee, beer and pulses for ochratoxin A. Food AdditContam1998;15:550-4.  Back to cited text no. 16
    
17. Wei L, Chen B, Ye R, Li H. Treatment of complications due to peritoneal dialysis for chronic renal failure with traditional Chinese medicine. J Tradit Chin Med 1999;19:3-9.  Back to cited text no. 17
[PUBMED]    
18. Zhang DN. Treatment of chronic renal failure with 'serial recipes for renal failure': A report of 64 cases. J Tradit Chin Med 1989;9:159-62.  Back to cited text no. 18
[PUBMED]    
19. Foote J, Cohen B. Medicinal herb use and the renal patient. J Renal Nutr1998;8:40-2.  Back to cited text no. 19
[PUBMED]    
20. Jha V, ChughKS. Nephropathy associated with animal, plant, and chemical toxins in the tropics. SemNephrol2003;23:49-65.  Back to cited text no. 20
    
21. Chou WC, Wu CC, Yang PC, Lee YT. Hypovolemic shock and mortality after ingestion of Tripterygiumwilfordii hook F: A case report. Int J Cardiol1995;49:173-7.  Back to cited text no. 21
[PUBMED]    
22. Eswarappa S, ChakrabortyAR, Palatty BU, Vasnaik M. Cleistanthuscollinuspoisoning: Case reports and review of the literature. J Toxicol ClinToxicol2003;41:369-72.  Back to cited text no. 22
    
23. Lin CC, Chen JC. Medicinal herb ErycibehenriPrain ('Ting Kung Teng') resulting in acute cholinergic syndrome. J ToxicolClinToxicol2002;40:185-7.  Back to cited text no. 23
[PUBMED]    
24. Hsu HY, Lin CC, Chen JY, Yang JJ, Zhang R. Toxic effects of Erycibeobtusifolia, a Chinese medicinal herb, in mice. J Ethnopharmacol1998;62:101-5.  Back to cited text no. 24
[PUBMED]    
25. Akdogan M, Kilinc I, Oncu M, Karaoz E, Delibas N. Investigation of biochemical and histopathological effects of MenthapiperitaL. &MenthaspicataL. on kidney tissue in rats. Hum ExpToxicol2003;22:213-9.  Back to cited text no. 25
    
26. Bwititi P, Musabayane CT, Nhachi CF. Effects of Opuntiamegacanthaon blood glucose and kidney function in streptozotocin diabetic rats. J Ethnopharmacol2000;69:247-52.  Back to cited text no. 26
[PUBMED]    
27. Powell T, Hsu FF, Turk J, Hruska K. Ma-huang strikes again: Ephedrine nephrolithiasis. Am J Kidney Dis 1998;32:153-9.  Back to cited text no. 27
    
28. Adesunloye BA. Acute renal failure due to the herbal remedy CKLS. Am J Med 2003;115:506-7.  Back to cited text no. 28
[PUBMED]    
29. Wojcikowski K, Johnson D, Gobe G. Medicinal herbal extracts-renal friend or foe? Part one: The toxicities of medicinal herbs. Nephrology 2004;9:313-8.  Back to cited text no. 29
    
30. Moschella C, Jaber BL. Interaction between cyclosporine and Hypericumperforatum(St. John'swort) after organ transplantation. Am J Kidney Dis 2001;38:1105-7.  Back to cited text no. 30
[PUBMED]    
31. Gaston RS. Maintenance immunosuppression in the renal transplant recipient: An overview. Am J Kidney Dis 2001;38(Suppl 6):S25-35.  Back to cited text no. 31
    
32. Bauer S, Stormer E, Johne A, Krüger H, Budde K, Neumayer HH, et al.Alterations in cyclosporin A pharmacokinetics and metabolism during treatment with St John's wort in renal transplant patients. Br J ClinPharmacol2003;55:203-11.  Back to cited text no. 32
    
33. Windrum P, Hull DR, Morris TC. Herb-drug interactions. Lancet 2000;355:1019-20.  Back to cited text no. 33
[PUBMED]    
34. Thevenod F. Nephrotoxicity and the proximaltube: Insight from cadmium. Nephron Physiol 2003;93:87-93.  Back to cited text no. 34
    
35. Ernst E. Harmless herbs? A review of the recent literature. Am J Med 1998;104:170-8.  Back to cited text no. 35
[PUBMED]    
36. Ko RJ. Adulterants in Asian patent medicines. N Engl J Med 1998;339:847.  Back to cited text no. 36
[PUBMED]    
37. Liu SY, Woo SO, Koh HL. HPLC and GC-MS screening of Chinese proprietary medicine for undeclared therapeutic substances. J Pharm Biomed Anal 2001;24:983-92.  Back to cited text no. 37
[PUBMED]    
38. Ernst E, Coon JT. Heavy metals in traditional Chinese medicines: A systematic review. ClinPharmacolTher2001;70:497-505.  Back to cited text no. 38
    
39. Howard H, Berger A. Alopecia and Sensory Polyneuropathy from thallium in a Chinese herbal medication. JAMA 1992;268:3430-1.  Back to cited text no. 39
    
40. AbtAB, Oh JY, Huntington RA, Burkhart KK. Chinese herbal medicine induced acute renal failure. Arch Intern Med 1995;155:211-2.  Back to cited text no. 40
    
41. DwivediSK, Dey S. Medicinal herbs: A potential source of toxic metal exposure for man and animals in India. Arch Environ Health 2002;57:229-31.  Back to cited text no. 41
    
42. Mandal BK, Chowdhury TR, Samanta G, Mukherjee DP, Chanda CR, Saha KC, et al.Impact of safe water for drinking and cooking on five arsenic-affected families for 2 years in West Bengal, India. Sci Total Environ 1998;218:185-201.  Back to cited text no. 42
[PUBMED]    
43. Saito T, Tsuboi Y, Fujisawa G, Sakuma N, Honda K, Okada K, et al.An autopsy case of licoriceinduced hypokalemic rhabdomyolysis associated with acute renal failure: Special reference to profound calcium deposition in skeletal and cardiac muscle. Nippon JinzoGakkai Shi 1994;36:1308-14.  Back to cited text no. 43
[PUBMED]    
44. Ascherio A, Rimm EB, Hernan MA, Giovannucci EL, Kawachi I, Stampfer MJ, et al. Intake of potassium, magnesium, calcium, and fiber and risk of stroke among US men. Circulation 1998;98:1198-204.  Back to cited text no. 44
    
45. Subat-Dezulovic M, Slavic I, Rozmanic V, Persic M, Medjimurec B, Scukanec-Spoljar M. Drug-induced acute tubulointerstitial nephritis: A case with elevated urinary cadmium. PediatrNephrol2002;17:382-5.  Back to cited text no. 45
    
46. Ige SF, Salawu EO, Olaleye SB, Badmus J, Adeleke AA. Onion (Allium cepa) extract preventcadmium induced renal dysfunction. Indian J Nephrol 2009;19:140-4.  Back to cited text no. 46
[PUBMED]  Medknow Journal  
47. Kwok TC, Chan TY, Woo J. Relationship of urinary sodium/potassium excretion and calcium intake to blood pressure and prevalence of hypertension among older Chinese vegetarians. Eur J ClinNutr 2003;57:299-304.  Back to cited text no. 47
[PUBMED]