Study of association between promoter tumor necrosing factor alpha gene polymorphisms in -850T/C, -863 A/C, and endometriosis


1 Department of Obstetrics and Gynecology, Isfahan University of Medical Sciences, Isfahan, Iran

2 Department of Anatomical Sciences, Head of Infertility Laboratory, Beheshti Hospital, Isfahan University of Medical Sciences, Isfahan, Iran

3 Department of Genetics, Medical School, Isfahan University of Medical Sciences, Isfahan, Iran


Background: The purpose of this study was to determine whether variability in gene encoding for promoter of tumor necrosis factor participates to women differences in susceptibility to endometriosis.
Materials and Methods: The study involved 130 women; 65 endometriotic and 65 healthy control women. The blood samples were genotyped for -850 T/C and -863 C/A polymorphisms in TNF alpha gene promoter. Chi-square, odd ratio, and confidence interval 95% were used to evaluate genotypes and allele frequency differences between two groups.
Results: No significant differences in genotypes distribution of -850 T/C (P = 0.32) and 863 C/A (P = 0.34) polymorphisms were obtained between two groups.
Conclusion: According to this study, these two polymorphisms have no risk or protective factor to develop endometriosis.


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