The epidemiological aspects of congenital heart disease in central and southern district of Iran


Yazd Cardiovascular Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran


Background: Congenital heart disease (CHD) is a major health problem and its prevalence is different around the world. The aim of study was determination of the epidemiological aspects of CHD in central and southern district of Iran.
Materials and Methods: In this descriptive and analytical study, 3714 medical records were evaluated from March 21, 2001 to December 18, 2011. Medical records of inpatients from angiography and outpatients in the Heart Clinic of Afshar hospital (a referral hospital in center and south of Iran) were the source of information. Types of CHD and demographic data including age, sex and residential location are collected. The data were analyzed by SPSS (version 17) software. Chi-square and Fisher's exact tests were used to compare variables between groups.
Results: At the study, the mean age of the patients at diagnosis time was 8.8 ± 11.6 year (at the range of one day to 76 years with median of 4 years). The percentage of females and males was 54.2 (n: 2014) and 43.8 (n: 1627), respectively. The chi-square test showed that there was significant difference in frequency of CHDs between females and males (P value < 0.0001). Ventricular septal defect (VSD) was found to be the most frequent of CHDs (27%). Patent ductus arteriosus (PDA) (16.8%), atrial septal defect (ASD) (15.8%), pulmonary stenosis (PS) (11%) and Tetralogy of Fallot (TOF) (8.9%) were more prevalent in CHDs after VSD.
Conclusions: The frequency of CHDs in female was more than male and VSD, PDA, ASD, PS, and TOF were most common in CHDs, respectively.


Nikyar B, Sedehi M, Mirfazeli A, Qorbani M, Golalipour MJ. Prevalence and pattern of congenital heart disease among neonates in Gorgan, Northern Iran (2007-2008). Iran J Pediatr 2011;21:307-12.  Back to cited text no. 1
Begic´ H, Tahirovic´ H, Mesihovic´-Dinarevic´ S, Ferkovic´ V, Atic´ N, Latifagic´ A. Epidemiological and clinical aspects of congenital heart disease in children in Tuzla Canton, Bosnia-Herzegovina. Eur J Pediatr 2003;162:191-3.  Back to cited text no. 2
Rahim F, Ebadi A, Saki G, Remazani A. Prevalence of congenital heart disease in Iran: A clinical study. J Med Sci 2008;8:547-52.  Back to cited text no. 3
Bolisetty S, Daftary A, Ewald D, Knight B, Wheaton G. Congenital heart defects in Central Australia. Med J Aust 2004;180:614-7.  Back to cited text no. 4
Bassili A, Mokhtar SA, Dabous NI, Zaher SR, Mokhtar MM, Zaki A. Congenital heart disease among school children in Alexandria, Egypt: An overview on prevalence and relative frequencies. J Trop Pediatr 2000;46:357-62.  Back to cited text no. 5
Smitha R, Karat SC, Narayanappa D, Krishnamurthy B, Prasanth SN, Ramachandra NB. Prevalence of congenital heart diseases in Mysore. Indian J Hum Genet 2006;12:11-6.  Back to cited text no. 6
  Medknow Journal  
Subramanyan R, Joy J, Venugopalan P, Sapru A, al Khusaiby S. Incidence and spectrum of congenital heart disease in Oman. Ann Trop Paediatr 2000;20:337-41.  Back to cited text no. 7
Alabdulgader AA. Congenital heart disease in 740 subjects: Epidemiological aspects. Ann Trop Paediatr 2001;21:111-8.  Back to cited text no. 8
Alnajjar AA, Morsy MF, Almuzainy IS, Sheikh AA. Pediatric heart diseases in Madina, Saudi Arabia. Current status and future expectations. Saudi Med J 2009;30:1186-91.  Back to cited text no. 9
Bosi G, Scorrano M, Tosato G, Forini E, Chakrokh R. The Italian multicentric study on epidemiology of congenital heart disease: First step of the analysis. Working Party of the Italian Society of Pediatric Cardiology. Cardiol Young 1999;9:291-9.  Back to cited text no. 10
Grech V, Gatt M. Syndromes and malformations associated with congenital heart disease in a population-based study. Int J Cardiol 1999;68:151-6.  Back to cited text no. 11
Mackie AS, Ionescu-Ittu R, Therrien J, Pilote L, Abrahamowicz M, Marelli AJ. Children and adults with congenital heart disease lost to follow-up: Who and when? Circulation 2009;120:302-9.  Back to cited text no. 12
Mocumbi AO, Lameira E, Yaksh A, Paul L, Ferreira MB, Sidi D. Challenges on the management of congenital heart disease in developing countries. Int J Cardiol 2011;148:285-8.  Back to cited text no. 13
Pradat P. Noncardiac malformations at major congenital heart defects. Pediatr Cardiol 1997;18:11-8.  Back to cited text no. 14
Robida A, Folger GM, Hajar HA. Incidence of congenital heart disease in Qatari children. Int J Cardiol 1997;60:19-22.  Back to cited text no. 15
Sani MU, Mukhtar-Yola M, Karaye KM. Spectrum of congenital heart disease in a tropical environment: An echocardiography study. J Natl Med Assoc 2007;99:665-9.  Back to cited text no. 16
Hiraishi S, Agata Y, Nowatari M, Oguchi K, Misawa H, Hirota H, et al. Incidence and natural course of trabecular ventricular septal defect: Two-dimensional echocardiography and color Doppler flow imaging study. J Pediatr 1992;120:409-15.  Back to cited text no. 17
Hoffman JI, Kaplan S. The incidence of congenital heart disease. J Am Coll Cardiol 2002;39:1890-900.  Back to cited text no. 18
Roguin N, Du ZD, Barak M, Nasser N, Hershkowitz S, Milgram E. High prevalence of muscular ventricular septal defect in neonates. J Am Coll Cardiol 1995;26:1545-8.  Back to cited text no. 19
Anderson CE, Edmonds LD, Erickson JD. Patent ductus arteriosus and ventricular septal defect: Trends in reported frequency. Am J Epidemiol 1978;107:281-9.  Back to cited text no. 20
Ooshima A, Fukushige J, Ueda K. Incidence of structural cardiac disorders in neonates: An evaluation by color Doppler echocardiography and the results of a 1-year follow-up. Cardiology 1995;86:402-6.  Back to cited text no. 21
Marelli AJ, Mackie AS, Ionescu-Ittu R, Rahme E, Pilote L. Congenital heart disease in the general population: Changing prevalence and age distribution. Circulation 2007;115:163-72.  Back to cited text no. 22