Advanced Biomedical Research

Salivary IgA and IgG in oral lichen planus and oral lichenoid reactions diseases

Authors

1 Department of Oral Medicine and Torabinejad Dental Research Center, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran

2 Department of School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran

3 Department of Epidemiologist, Isfahan University of Medical Sciences, Isfahan, Iran

Abstract

Background: The objective of this study was to assess the level of salivary IgA and IgG in oral lichen planus (OLP) and oral lichenoid reactions (OLR) patients as diagnostic factors to the differential diagnosis of OLP, OLR diseases.
Materials and Methods: Saliva sample were obtained from 50 OLP, 50 OLR patients and 50 healthy subjects between April 2010 and October 2011. The clinical relevant data taken into account were: Demographical data, previous medication, and level of salivary IgA and IgG. Each sample was assessed to determine the level of salivary IgA by ELISA test and salivary IgG by radial immune diffusion.
Results: The mean of salivary IgA and IgG in patients were 119.01 ± 114.18 mic/ml and 3.25 ± 1.81 mic/ml, respectively. There were no significant differences for salivary IgA and IgG between OLP and OLR, but the mean of salivary IgA and IgG in OLP and OLR patients were significantly more than normal group (P-value < 0.05). The cut-off value was set at >72 mic/ml for salivary IgA in both OLP and OLR groups and set at >3.7 mic/ml for salivary IgG. On comparing the AUCs, there was no significant difference between AUCs for IgA (0.715 ± 0.05vs. 0.69 ± 0.5, for OLP and OLR patients, respectively,P-value = 0.7) and IgG (0.681 ± 0.05 vs. 0.548 ± 0.06, for OLP and OLR patients, respectively, P-value = 0.1).
Conclusions: Our results showed that the level of salivary IgA and IgG in OLP and OLR patients is higher than healthy controls, but they cannot be used as diagnostic factors to the differential diagnosis of OLP and OLR.

Keywords

1. Fernández-González F, Vázquez-Álvarez R, Reboiras-López D, Gándara-Vila P, García-García A, Gándara-Rey JM. Histopathological findings in oral lichen planus and their correlation with the clinical manifestations.Med Oral Patol Oral Cir Bucal 2011;16:641-6.  Back to cited text no. 1
    
2. Sugerman PB, Savage NW, Walsh LJ, Zhao ZZ, Zhou XJ, Khan A, et al.The pathogenesis of oral lichen planus.Crit Rev Oral Biol Med 2002;13:350-65.  Back to cited text no. 2
    
3. Torrente-Castells E, Figueiredo R, Berini-Aytés L, Gay-Escoda C. Clinical features of oral lichen planus. A retrospective study of 65 cases. Med Oral Patol Oral Cir Bucal 2010;15:685-90.  Back to cited text no. 3
    
4. Nagao T, Ikeda N, Fukano H, Hashimoto S, Shimozato K, Warnakulasuriya S. Incidence rates for oral leukoplakia and lichen planus in a Japanese population. J Oral Pathol Med 2005;34:532-9.  Back to cited text no. 4
    
5. Edwards PC, Kelsch R. Oral lichen planus: Clinical presentation and management. J Can Dent Assoc 2002;68:494-9.  Back to cited text no. 5
    
6. Laeijendecker R, Joost TV, Tank B, Oranje AP, Neumann HA. Oral lichen planus in childhood.Pediatr Dermatol 2005;22:299-304.  Back to cited text no. 6
    
7. Mignogna MD, Lo Russo L, Fedele S. Gingival involvement of oral lichen planus in a series of 700 patients. J ClinPeriodontol 2005;32:1029-33.  Back to cited text no. 7
    
8. Pindborg JJ, Reichart PA, Smith CJ, van der Waal I. Histological typing of cancer and precancer of the oral mucosa. 2nd ed. Berlin: Springer (World Health Organization International Histological Classification of Tumours);1997. p. 87.  Back to cited text no. 8
    
9. Ismail SB, Kumar SKS, Zain RB. Oral lichen planus and lichenoid reactions: Etiopathogenesis, diagnosis, management and malignant transformation. J Oral Sci 2007;49:89-106.  Back to cited text no. 9
    
10. Scully C, Beyli M, Ferreiro MC. Update on oral lichen planus: Etiopathogenesisand management. Crit Rev Oral Biol Med 1998;9:86-122.  Back to cited text no. 10
    
11. Eisen D, Carrozzo M, Bagan Sebastian JV, Thongprasom K. Number V Oral lichen planus: Clinical features and management. Oral Dis 2005;11:338-49.  Back to cited text no. 11
    
12. Al-Hashimi I, Schifter M, Lockhart PB, Wray D, Brennan M, Migliorati CA, et al. Oral lichen planus and oral lichenoid lesions: Diagnostic and therapeutic considerations. Oral Surg Oral Med Oral Pathol Oral RadiolEndod 2007;103:1-12.  Back to cited text no. 12
    
13. Laine J, Kalimo K, Happonen RP. Contact allergy to dental restorative materials in patients with oral lichenoid lesions. Contact Dermatitis 1997;36:141-6.  Back to cited text no. 13
    
14. Ibbotson SH, Speight EL, Macleod RI, Smart ER, Lawrence M. Relevance and effect of amalgam replacement in subjects with oral lichenoid reactions. Br J Dermatol 1996;134:420-3.  Back to cited text no. 14
    
15. Kalimo K. Oral lichenoid lesions caused by allergy to mercury in amalgam fillings. Contact Dermatitis 1996;35:69.  Back to cited text no. 15
    
16. Blongren J, Axéll T, Sandahl O, Jontell M. Adverse reactions in the oral mucosa associated with anterior composite restorations. J Oral Pathol Med 1996;25:311-3.  Back to cited text no. 16
    
17. McCartanBE, McCreary CE. Oral lichenoid drug eruptions. Oral Dis 1997;3:58-63.  Back to cited text no. 17
    
18. Menni S, Barbareschi M, Fargetti G, Hendrickx I. Lichenoid eruptions of the mouth mucosa induced by lithium carbonate. 2 cases. Ann DermatolVenereol 1995;122:91-3.  Back to cited text no. 18
    
19. Miller RL, Gould AR, Bernstein ML. Cinnamon-induced stomatitis venenata, clinical and characteristic histopathologic features. Oral Surg Oral Med Oral Pathol 1992;73:708-16.  Back to cited text no. 19
    
20. Morton CA, Garioch J, Todd P, Lamey PJ, Forsyth A. Contact sensitivity to menthol and peppermint in patients with intra-oral symptoms. Contact Dermatitis 1995;32:281-4.  Back to cited text no. 20
    
21. Do Prado RF, Marocchio LS, Felipini RC. Oral lichen planus versus oral lichenoid reaction: Difficulties in the diagnosis. Indian J Dent Res 2009;20:361-4.  Back to cited text no. 21
    
22. Thornhill MH, Pemberton MN, Simmons RK, Theaker ED. Amalgam-contact hypersensitivity lesions and oral lichen planus.Oral Surg Oral Med Oral Pathol Oral RadiolEndod 2003;95:291-9.  Back to cited text no. 22
    
23. Lind PO. Oral lichenoid reactions related to composite restorations. Preliminary report.ActaOdontolScand 1988;46:63-5.  Back to cited text no. 23
    
24. Van Loon LA, Bos JD, Davidson CL. Clinical evaluation of fifty-six patients referred with symptoms tentatively related to allergic contact stomatitis. Oral Surg Oral Med Oral Pathol 1992;74:572-5.  Back to cited text no. 24
    
25. Lodi G, Scully C, Carrozzo M, Griffiths M, Sugerman PB, Thongprasom K. Current controversies in oral lichen planus: Report of an international consensus meeting. Part 2.Clinical management and malignant transformation. Oral Surg Oral Med Oral Pathol Oral RadiolEndod 2005;100:164-78.  Back to cited text no. 25
    
26. Van der Meij EH, Van der Waal I. Lack of clinicopathologic correlation in the diagnosis of oral lichen planus based on the presently available diagnostic criteria and suggestions for modifications. J Oral Pathol Med 2003;32:507-12.  Back to cited text no. 26
    
27. Sistig S, Vucicevic-Boras V, Lukac J, Kusic Z. Salivary IgA and IgG subclasses in oral mucosal diseases. Oral Dis 2002;8:282-6  Back to cited text no. 27
    
28. Albanidou-Farmaki E, Kayavis I, Sideropoulos I, Papanayiotou P, Polymenidis Z. Serum immunoglobulins IgA, IgG and IgM, and oral lichen planus. Stomatologia 1990;47:114-120.  Back to cited text no. 28
    
29. Gandolfo S, Carrozzo M, Carbone M, Broccoletti R, Cascio G. Humoral immunological parameters in Italian patients with oral lichen planus. Bull Group Int Rech Sci Stomatol Odontol 1994;37:71-7.  Back to cited text no. 29
    
30. Ghalayani P, Razavi SM, Gholami D. Comparative study of number and distribution of IgG+ cells in oral lichen planus and oral lichenoid lesions. Dent Res J (Isfahan) 2009;6:1-5.  Back to cited text no. 30
    
31. Van der Waal I. Oral lichen planus and oral lichenoid lesions; A critical appraisal with emphasis on the diagnostic aspects. Med Oral Patol Oral Cir Bucal 2009;14:310-4.  Back to cited text no. 31
    
32. Wu-Wang CY, Patel M, Feng J, Milles M, Wang SL. Decreased levels of salivary prostaglandin E2 and epidermal growth factor in recurrent aphthous stomatitis. Arch Oral Biol 1995;40:1093-8.  Back to cited text no. 32
    
33. Hanley JA, McNeil BJ. The meaning and use of the area under a receiver operating characteristic (ROC) curve. Radiology 1982;143:29-36.  Back to cited text no. 33
    
34. Sano SM, Quarracino MC, Aguas SC, González EJ, Harada L, Krupitzki H, et al. Sensitivity of direct immunofluorescence in oral diseases. Study of 125 cases.Med Oral Patol Oral Cir Bucal 2008;13:287-91.  Back to cited text no. 34
    
35. Gombos F, Serpico R, Gaeta GM, Budetta F, De Luca P. The importance of direct immunofluorescence in the diagnosis of oral lichen planus. A clinical study and proposal of new diagnostic criteria.Minerva Stomatol 1992;41:363-72.  Back to cited text no. 35
    
36. Laskaris G, Sklavounou A, Angelopoulos A. Direct immunofluorescence in oral lichen planus.Oral Surg Oral Med Oral Pathol 1982;53:483-7.  Back to cited text no. 36
    
37. Biocina-Lukenda D, Cekiæ-Arambasin A, Markeljeviæ J, Bukoviæ D. Serum immunoglobulinsIgG, IgA and IgM in patients with oral lichen ruber.CollAntropol 2008;32:161-3.  Back to cited text no. 37
    
 
Advanced Biomedical Research
Volume 2012, October
October 2012
Pages 1-5