Case report on the administration of an eighty milligram diazepam injection without respiratory depression


1 Department of Cardiology, Isfahan University of Medical Sciences, Isfahan, Iran

2 Department of Internal Medicine, Isfahan University of Medical Sciences, Isfahan, Iran


Nowadays one of the most challenging problems in Medicine is addiction - addiction to sedative drugs such as benzodiazepines. In this article, we are going to describe a case of diazepam addiction that has tolerated a high dose of intravenous diazepam.


Sisk AL. Reduction of venous complications of intravenous diazepam. Anesth Prog 1985;32:241-3.  Back to cited text no. 1
Miller NS, Mahler JC. Addiction to and dependence on benzodiazepines. Diagnostic confusion in clinical practice and research studies. J Subst Abuse Treat 1991;8:61-7.  Back to cited text no. 2
Juergens S. Alprazolam and diazepam: Addiction potential. J Subst Abuse Treat 1991;8:43-51.  Back to cited text no. 3
Busto U, Kaplan HL, Zawertailo L, Sellers EM. Pharmacologic effects and abuse liability of bretazenil, diazepam, and alprazolam in humans. Clin Pharmacol Ther 1994;55:451-63.  Back to cited text no. 4
Bergman U, Griffiths RR. Relative abuse of diazepam and oxazepam: Prescription forgeries and theft/loss reports in Sweden. Drug Alcohol Depend 1986;16:293-301.  Back to cited text no. 5
Perdel V, Delga C, Rouby F, Micallef J, Lapeyre-Mestre M. Assessment of abuse potential of benzodiazepines from a prescription database using 'doctor shopping' as an indicator. CNS Drugs 2010;24:611-20.  Back to cited text no. 6
Litchfield NB. Complications of intravenous diazepam - adverse psychological reactions. (An assessment of 16,000 cases). Anesth Prog 1980;27:175-83.  Back to cited text no. 7
Stewart RC. Respiratory depression with diazepam: Potential complications and contraindications. Anesth Prog 1978;25:117-8.  Back to cited text no. 8
Davies G. Complication of diazepam administration. Can Anaesth Soc J 1977;24:418-9.  Back to cited text no. 9
Eloma MM, de C Williams AC, Kalso EA. Attention management as a treatment for chronic pain. Eur J Pain 2009;13:1062-7.  Back to cited text no. 10
Soliman HM, Mélot C, Vincent JL. Sedative and analgesic practice in the intensive care unit: The results of a European survey. Br J Anaesth 2001;87:186-92.  Back to cited text no. 11