Comparison the efficacy of ablative CO 2 laser and fractional CO 2 laser on the healing of cutaneous leishmaniasis scars


1 Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran

2 General Physician, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

3 Skin Diseases and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan, Iran


Background: The aim of this study is to compare ablative CO 2 laser with fractional CO 2 laser on healing of the wound and the size of cutaneous leishmaniasis scars.
Materials and Methods: This prospective randomized clinical trial study was done on 120 patients in two groups evaluated in Sedigheh Tahereh Hospital in Isfahan.
The patients in case group underwent one session ablative CO 2 laser for treatment of leishmaniasis scars and the patients in control group underwent si x 3-weeks interval sessions fractional CO 2 laser for treatment of leishmaniasis scars. All cases were evaluated from size and other aspects of scar by a questionnaire, and before and 6 months after photos were evaluated by blinded dermatologist. The data collected in the check list was then analyzed by t-test and Chi-square with SPSS 20.
Results: There were 60 people in case group and 60 in control group. The mean age was 27.21 ± 11.2. Our results show that fractional CO 2 laser is better than ablative CO 2 laser in various aspect of treatment of leishmaniasis scars (P < 0.05).
Conclusions: Fractional CO 2 laser is better than ablative CO 2 laser in variants aspect of treatment of leishmaniasis scars.


Berman ID. Human Leishmaniasis: Clinical, diagnostic and chemotherapeutic development in the last 10 years. Clin infect Dis 1997;24:684-703.  Back to cited text no. 1
World Health organization. Tropical Disease Research. 12 th program report. UNDP/World Bank/WHO Special program for research and Training Disease (TDR). Geneva: WHO; 1995. p. 135-49.  Back to cited text no. 2
Ardehali S, Rezaei H, Nadim A. Leishmania and Leishmaniasis. Tehran: University Publications Center; 1985. p. 149-60.  Back to cited text no. 3
Asilian A. Cutaneous Leishmaniasis: Prevention and Control. Isfahan: Isfahan University Publications; 1992. p. 52-68.  Back to cited text no. 4
Momeni A, Javaheri A, Tajdidi M, Emem JM. Glucantim in Leishmaniasis: Treatment outcomes and complications. J Nabz 1993;2:5-10.  Back to cited text no. 5
Vega Lopez F, Hay RJ. Parasitic Worm and protozoa In: Burns T, Breathnach S, Cox N, Griffiths CH, editors. Rooks text book of dermatology. 7 th ed. Malden: Blackwell Science; 2004. p. 32.42.  Back to cited text no. 6
Dowlati Y. Cutaneous Leishmaniasis: Clinical Aspect. Clin Dermatol 1996;14:425-31.  Back to cited text no. 7
Nilforoushzadeh MA, Jaffary F, Ansari N, Moradi S, Siadat AH. The comparison between trichloroacetic Acid 50% and co(2) laser in the treatment of cutaneous leishmaniasis scar. Indian J Dermatol 2011;56:171-3.  Back to cited text no. 8
[PUBMED]  Medknow Journal  
Thakur CP, Sinha GP, Pandey AK, Barat D, Singh RK. Daily versus alternate -day regimen of amphotericin B in the treatment of kala-azar: A randomized comparison. Bull World Health Organ 1994;72:931-6.  Back to cited text no. 9
Cassuto DA. Scrimali L, Sirago P. An innovative device for fractional CO2 resurfacing: A preliminary clinical study. Am J Cosm Surg 2008;25:97-101.  Back to cited text no. 10
Tanzi EL, Wanitphakdeedecha R, Alster TS. Fraxel laser indications and long-term follow-up. Aesthet Surg J 2008;28:675-8.  Back to cited text no. 11
Alster TS, Tanzi EL, Lazarus M. The use of fractional laser photodermolysis for the treatment of atrophic scars. Dermatol Surg 2007;33:295-9.  Back to cited text no. 12
Chrastii B, Gaichi SA, Goldberg LH, Friedman PM. Second-Generation 1,550-nm Fractional photothermolysis for the treatment of acne scars. Dermatol Surg 2008;34:1327-32.  Back to cited text no. 13
Rivera AE. Acne scarring: A review and current treatment modalities. J Am Acad Dermatol 2008;59:659-76.  Back to cited text no. 14
Nilforoushzadeh MA, Sadeghian G. Cutaneous Leishmaniasis. Isfahan: Isfahan University of Medical Sciences Publications; 2002. p. 157.  Back to cited text no. 15
Nilforoushzadeh MA, Jafari F, Ansari N, Moradi Sh. Comparison the efficacy of trichloroacetic in treatment of cutaneous leishmaniasis scar. Skin Quart 2007;41:183-9.  Back to cited text no. 16
Biotech Week. Reliant technologies, Inc; Reliant technologies announces U.S. FDA clearance of the Fraxel laser for acne and surgical scars. Atlanta: GMP publications, 2006. p. 971.  Back to cited text no. 17
Lee HS, Lee JH, Ahn GY, Lee DH, Shin JW, Kim DH, et al. Fractional photothermolysis for the treatment of acne scars: A report of 27 Korean patients. J Dermatolog Treat 2008;19:45-9.  Back to cited text no. 18
Alghamdi KM. Successful treatment of atrophic scars from cutaneous leishmaniasis using a fractional laser. J Cutan Med Surg 2010;14:303-6.  Back to cited text no. 19
Jamil AT, Muzaffar F, Nabi H, Malik S, Noreen A, et al. Efficacy and safety of ablative fractional carbon dioxide laser for acne scars. J Pak Assoc Dermatol 2012;22:41-4.  Back to cited text no. 20
Weiss ET, Chapas A, Brightman L, Hunzeker C, Hale EK, Karen JK, et al. Successful treatment of atrophic postoperative and traumatic scarring with carbon dioxide ablative fractional resurfacing: Quantitative volumetric scar improvement. Arch Dermatol 2010;146:133.  Back to cited text no. 21
Chapas AM, Lori B, Sean S, Hale E, Daniel D, Bernstein LJ, et al. Successful treatment of acneiform scarring with CO2 ablative fractional resurfacing. Lasers Surg Med 2008;40:381-6.  Back to cited text no. 22