Persistence of endothelial cell damage late after Kawasaki disease in patients without coronary artery complications

Authors
Nasser Mostafavi 1
Shaghayegh Haghjooy-Javanmard 2
Nahid Presidend 3
Nayereh Siyah Manssori 4
Roya Kelishadi 5
1 Departments of Pediatrics, Infectious Diseases and Tropical Medicine Research Center; Child Growth and Development Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
2 Department of Physiology, Applied Physiology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
3 Infectious Diseases and Tropical Medicine Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
4 Alzahra Hospital, Isfahan University of Medical Sciences, Isfahan, Iran
5 Child Growth and Development Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
Abstract
Background: Recent studies proposed an increased risk of atherosclerosis in patients with a history of Kawasaki disease. This study aimed to investigate the persistence of vascular injury after an acute phase of the Kawasaki disease.
Materials and Methods: We determined the number of circulating endothelial cells (CEC) in the peripheral blood of 13 patients with a history of Kawasaki disease within four to ten years, in comparison with 13 healthy relative controls. The CECs were counted as CD146+/CD34 + cells by the standard flow cytometry technique, and the independent t-test was employed to compare the mean number of CECs in the two groups.
Results: The mean number of CECs was significantly higher in patients than in controls (12 ± 3.03 vs. 2.38 ± 0.87, respectively, P < 0.001).
Conclusion: This study elucidates the persistence of vascular injury late after Kawasaki disease. This finding suggests that prolonged administration of vascular anti-inflammatory agents might be beneficial for preventing atherosclerosis in the subsequent years, in these patients.

Keywords

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Advanced Biomedical Research
Volume 2015, January
January 2015
Pages 1-5