Effects of aerobic exercise on plasma lipoproteins in overweight and obese women with polycystic ovary syndrome


1 Faculty of Physical Education and Sports Science, Islamic Azad University Khorasghan (Isfahan) Branch, Isfahan, Iran

2 Department of Obstetric and Gynecology, Isfahan University of Medical Sciences, Isfahan, Iran

3 Faculty of Nursing and Midwifery, Islamic Azad University Khorasghan (Isfahan) Branch, Isfahan, Iran


Background: Polycystic ovary syndrome (PCOS) is one of the most frequent endocrine disorders. The PCOS manifest by hyperandrogenism, hypertension and cholesterol and lipoprotein improper profiles. Changing the life style, e.g. increasing physical activities is the first approach in controlling PCOS.
Materials and Methods: Twenty-four women affected by polycystic ovary syndrome (PCOS) after medical screening were divided in to two groups: Experimental group (n = 12) and control group (n = 12), with the average age, weight, height, BMI and WHR of 26.87 ± 4.43 years, 75.71 ± 10.65 kg. 159.29 ± 6.44 cm, 29.86 ± 3.22 kg/m 2 and 91.75 ± 5.86 respectively. First the body composition such as BMI, WHR, percent body fat, weight and body fat mass were measured. In fasting blood samples the level of HDL, LDL, VLDL, triglyceride and cholesterol were measured. Then the experiment group underwent the effect of an aerobic exercise program. After 12 weeks, all the measured variables before intervention the test were re-measured. Correlated t-test was used for comparing the two groups before and after intervention the test and independent t-test was used for comparing the two groups (P < 0.05).
Results: The results showed that after 12 weeks of exercise, BMI, WHR, fat rate, weight and fat mass and triglyceride had significant reduction and HDL had significant increase. But no significant changes happened in LDL, VLDL, and cholesterol levels.
Conclusion: Reducing the weight by aerobic exercise in obese women and affected by PCOS can correct lipoprotein profile and improving health.


Harrison CL, Lombard CB, Moran LJ, Teede HJ. Exercise therapy in polycystic ovary syndrome: A systematic review. Hum Reprod Update 2011;17:171-8.  Back to cited text no. 1
Hirschberg AL. Polycystic ovary syndrome, obesity and reproductive implications. Womens Health (Lond Engl) 2009;5:529-40.  Back to cited text no. 2
Speroffl MF. Clinical gynecology endocrinology and infertility. 7 th ed. Philadelphia: Lippincott Williams and Williams 2005. p. 465.  Back to cited text no. 3
Pasquali R, Casimirri F, Ralestra V, Flamia R, Melchionda N, Fabbri R, et al. The relative contribution of androgens and insulin in determining abdominal fat distribution inpremenopausal women. J Endo Crinol Invest 1991;14:839.  Back to cited text no. 4
Hoeger KM. Exercise Therapy in Polycystic Ovary Syndrome. Semin Reprod Med 2008;26:93-100.  Back to cited text no. 5
Jonathan S. Berek's. Berek and Novak's Gynecology.15. 14 th ed. Philadelphia: Lippincott Williams and Wilkins; 2011.  Back to cited text no. 6
Apridonidze T, Essah PA, Iuorno MJ, Nestler JE. Prevalence Characteristics of the Metabolic Syndrome in Women with Polycystic Ovary Syndrome. Clin Endocrinol Metab 2005;90:1929-35.  Back to cited text no. 7
Azziz R, Ehrmann D, Legro RS, Whitcomb RW, Hanley R, Fereshetian AG, et al. Troglitazone improves ovulation and hirsutism in the polycystic ovary syndrome: A multicenter, double blind, placebo-controlled trial. J Clin Endocrinol Metab 2001;86:1626-32.  Back to cited text no. 8
Legato MJ. Gender-specific aspects of obesity. Int J Fertil Womens Med 1997;42:184-97.   Back to cited text no. 9
Bjorntorp P. Abdominal obesity and the metabolic syndrome. Ann Med 1992;24:465-8.  Back to cited text no. 10
Motta AB. The role of obesity in the development of polycystic ovary syndrome. Curr Pharm Des 2012;18:2482-91.  Back to cited text no. 11
Speroff LM. Clinical endocrinology of women, and infertility. Lippincott Williams & Wilkins, Philadelphia, Pa, USA, 8th edition 2011. p. 508.  Back to cited text no. 12
Mardanian F, Heidari N. Diagnostic value of PSA I women with PCOS. J RES Med Sci 2011;16:999-1005.  Back to cited text no. 13
[PUBMED]  Medknow Journal  
Lord JM, Flight IH, Norman RJ. Metformin in polycystic ovary syndrome: Systematic review and meta-analysis. Br Med J 2003;327:957-5.  Back to cited text no. 14
Clarke A, Thornley B, Tomlinson L, Galletly C, Norman R. Weight loss in obest infertile women resulte in improvement in reproductive out come for all forms of fertility treatment. J Hum Repro1998;13:1502-6.  Back to cited text no. 15
Karimi ZA, Naghi CM. Prevalence of the risk factor of coronary artery disease and the effect of instructions for modifying living standards. Kosar 2009;3:157-62.  Back to cited text no. 16
Moran LJ, Harrison CL, Hutchison SK, Stepto NK, Strauss BJ, Teede HJ. Exercise decreases anti-müllerian hormone in anovulatory overweight women with polycystic ovary syndrome. Horm Metab Res 2011;43:977-9.  Back to cited text no. 17
Hoeger KM. Obesity and lifestyle management in polycystic ovary syndrome. Clin Obstet Gynecol 2007;50:277-94.  Back to cited text no. 18
Salarkya N. Effect of exercise and diet with limited eatery to fat and lipoproteins of blood. Med Sports 2000;25:61-2.  Back to cited text no. 19
Palomba S, Giallauria F, Falbo A, Russo T, Oppedisano R, TolinoA, et al. Structured exercise training programme versus hypocalorichy perproteic diet in obese polycystic ovary syndrome patients with anovulatory infertility: A 24-week pilot study. Hum Reprod 2008;23:642-50.  Back to cited text no. 20
Pasquali R, Casimirri F, Ralestra V, Flamia R, Melchionda N, Fabbri R, et al. The relative contribution of androgens and insulin in determining abdominal fat distribution inpremenopausal women. J Endo Crinol Invest 1991;14:839.  Back to cited text no. 21
Pfiifer SM, Dayal M. Treatment of the adoleseentpate in with polycystic ovary syndrome. Obstet Gynecol Clin North Am 2003;30:337-52.  Back to cited text no. 22
Zafari A, Eftekhari E, Rostami M. Relation between physical activity and lipo protein serumlept in concentrations in obese women. Viewed articlesirst National Conference on Physical Education and Sport Sciences. Islamic Azad University Najafabad. 2012; p.117.  Back to cited text no. 23
KimaraY, Ohki K, Yamazaki S. Effects of exercise on body composition, lipids, and bone status in overweight women. Phys Ther 2000;24-31.  Back to cited text no. 24
Hutchison SK, Stepto NK, Harrison CL, Moran LJ, Strauss BJ, Teede HJ. Effects of Exercise on Insulin Resistance and Body Composition in Overweight and Obese Women with and without Polycystic Ovary Syndrome. J Clin Endocrinol Metab 2011;96:48-5.  Back to cited text no. 25
Stener-Victorin E, Jedel E, Janson PO, Sverrisdottir YB. Low-frequency electroacupuncture and physical exercise decrease high muscle sympathetic nerve activity in polycystic ovary syndrome. Am J Physiol Regul Integr Comp Physiol 2009;297:387-95.  Back to cited text no. 26
Vigorito C, Giallauria F, Palomba S, Cascella T, Manguso F, Lucci R, et al. Beneficial effects of a three-month structured exercise training program on cardiopulmonary functional capacity in young women with polycystic ovary syndrome. J Clin Endocrinol Metab 2007;92:1379-84.  Back to cited text no. 27
Giallauria F, Palomba S, Maresca L, Vuolo L, Tafuri D, Lombardi G, et al. Exercise training improves autonomic function and inflammatory pattern in women with polycystic ovary syndrome (PCOS). Clin Endocrinol 2008;69:792-8.  Back to cited text no. 28
Thomson RL, Buckley JD, Noakes M, Clifton PM, Norman RJ, Brinkworth GD. The effect of a hypocaloric diet with and without exercise training on body composition, cardio metabolic risk profile, and reproductive function in overweight and obese women with polycystic ovary syndrome. J Clin Endocrinol Metab 2008;93:3373-80.  Back to cited text no. 29
Bruner B, Chad K, Chizen D. Effects of exercise and nutritional counseling in women with polycystic ovary syndrome. Appl Physiol Nutr Metabol 2006;31:384-91.  Back to cited text no. 30
Randeva HS, Lewandowski KC, Drzewoski J, Brooke-Wavell K, O'Callaghan C, Czupryniak L, et al. Exercise Decreases plasma total homocysteine in overweight young women With polycystic ovary syndrome. J Clin Endocrinol Metab 2002;87:4496-501.  Back to cited text no. 31
Brown AJ, Setji TL, Sanders LL, Lowry KP, Otvos JD, Kraus WE, et al. Effects of exercise on lipoprotein particles in women with polycystic ovary syndrome. Med Sci Sports Exerc 2009;41:497-504.  Back to cited text no. 32
Tofighi A, Trtybyan B, Seydamery M, Najafi S, Asemi A. Effect of aerobic exercise on hormone levels in women affected by PCOS. Medical Urmia 2010;4:332-8.  Back to cited text no. 33
Maughan R, Gleeson M, Greenhaff P. Biochemistry of exercise and training. Informa Healthcare. 1 st ed. Oxford University Press, USA; 1997.  Back to cited text no. 34
Nicklas B, Endurance Exercise and Adipose Tissue. USA: Oxford University Press; 2002.  Back to cited text no. 35
Tymchuk CN, Tessler SB, Barnard RJ. Changes in sex hormone-binding globulin, insulin and serum lipids in postmenopausal women on a low-fat, high-fiber diet combined with exercise. J Nutr Cancer 2000;38:158-62.  Back to cited text no. 36