Advanced Biomedical Research
Type 2 diabetes mellitus and renal stones
Authors
- Rajendra Nerli 1
- Mallikarjuna Jali 2
- Ajay Kumar Guntaka 1
- Pravin Patne 1
- Shivagouda Patil 1
- Murigendra Basayya Hiremath 3
1 Department of Urology, KLES Kidney Foundation, Karnatak University, Karnataka, India
2 KLES Diabetes Centre, Jawaharlal Nehru Medical College, KLES Dr. Prabhakar Kore Hospital and Medical Research Centre, KLE University, Karnataka, India
3 Department of Biotechnology and Microbiology, Karnatak University, Karnataka, India
Abstract
Background: The incidence of urinary stone disease has shown a steep rise in recent decades along with marked modifications in dietary habits and life- style. There has been an increased prevalence of urinary stone disease in patients with diabetes. We took up this study to determine the association of diabetes mellitus with kidney stones in patients undergoing surgical treatment.
Materials and Methods: Patients presenting with renal stones for surgical management formed the study group. Body mass index (BMI) was calculated by noting the weight and height of the patient. The extracted stone/stone fragments were analyzed to determine the chemical composition. Urinary pH was similarly noted in all.
Results: The mean BMI among the diabetics was 26.35 ± 5.20 (range 17.75-35.60), whereas the mean BMI among the non-diabetics was 23.41 ± 2.85 (range 17.71-31.62) (P < 0.0004). The incidence of uric acid calculi in the diabetics was significantly high (P < 0.03). The mean urinary pH among the diabetics was 5.61 ± 0.36 and among the non-diabetics was 6.87 ± 0.32, which was significantly lower (P < 0.000044).
Conclusions: There is a strong association between type 2 diabetes and uric acid stone formation. There is also a strong association between diabetes mellitus, BMI, and also with lower urinary pH.
Keywords
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