Is chronic kidney disease, a predictor of in-hospital mortality in Coronavirus Disease 2019 (COVID-19) patients?

Authors
Firouzeh Moeinzadeh 1
Vahideh Raeisi 2
Media Babahajiani 3
Mojgan Mortazavi 1
Samaneh Pourajam 2
Shiva Seirafian 1
Mohammad Shirzadi 2
Shahram Taheri 1
Mehrdad Salahi 4
Marjan Mansourian 5
Arash Toghyani 6
Zahra Zamani 1
1 Isfahan Kidney Diseases Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
2 Department of Internal Medicine, Medical School, Isfahan University of Medical Sciences, Isfahan, Iran
3 Student Research Committee, Vice Chancellor for Research and Technology, Kurdistan University of Medical Sciences, Sanandaj, Iran
4 Department of Infectious Disease, Medical School, Isfahan University of Medical Sciences, Isfahan, Iran
5 Epidemiology and Biostatics Department, School of Health, Isfahan University of Medical Sciences, Isfahan, Iran
6 Medical School, Isfahan University of Medical Sciences, Isfahan, Iran
Abstract
Background: Chronic kidney disease (CKD) is an important comorbidity in Coronavirus Disease 2019 (COVID-19) patients considering its high prevalence. We aimed to figure out the relationship between CKD and COVID-19 mortality in this study.
Materials and Methods: In total, 116 CKD patients (estimated glomerular filtration rate [eGFR] lower than 60 mL/min/1.73 m2) and 147 control subjects confirmed with COVID-19 were studied. Data regarding demographics, sign and symptoms, laboratory findings, and chest computed tomography were collected. Association between CKD and in-hospital mortality were analyzed using logistic regression models adjusted for confounders.
Results: Mortality rate was significantly higher in CKD than non-CKD (30.17 vs 4.76, P < 0.001) COVID-19 patients. Multivariate logistic regression showed that CKD was significantly correlated with in-hospital mortality in the total sample (Odds ratio (OR) = 8.64, confidence interval (CI): 3.67–20.35) and gender subgroups (females: OR = 4.77, CI: 1.38–16.40, males: OR = 13.43, CI: 3.85–46.87) (P < 0.05) of COVID-19 patients in the crude model. Whereas, the correlation did not remain significant in the fully adjusted model in the total sample (OR = 1.70, CI: 0.35–8.19) and gender subgroups (females: OR = 1.07 CI: 0.06–19.82, males: OR = 0.87, CI: 0.07–10.33) (P > 0.05) of COVID-19 patients.
Conclusion: This study suggested an independent association between CKD and in-hospital mortality in COVID-19 patients. Therefore, more intensive surveillance of COVID-19 patients with CKD is to be warranted.

Keywords

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Advanced Biomedical Research
Volume 2023, February
February 2023
Pages 1-9