Rolipram: Eotaxin and phosphodiesterase IV inhibitor versus bronchial hyper-reactivity response

Letter to Editor


Shifa College of Medicine, Shifa Tameer-e-Millat University, Islamabad, Pakistan

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BinMahfouz H, Borthakur B, Yan D, George T, Giembycz MA, Newton R. Superiority of combined phosphodiesterase PDE3/PDE4 inhibition over PDE4 inhibition alone on glucocorticoid- and long-acting β2-adrenoceptor agonist-induced gene expression in human airway epithelial cells. Mol Pharmacol 2015;87:64-76.  Back to cited text no. 2
Lucarini L, Pini A, Gerace E, Pellicciari R, Masini E, Moroni F. Poly (ADP-ribose) polymerase inhibition with HYDAMTIQ reduces allergen-induced asthma-like reaction, bronchial hyper-reactivity and airway remodelling. J Cell Mol Med 2014;18:468-79.  Back to cited text no. 3
Patel BS, Prabhala P, Oliver BG, Ammit AJ. Inhibitors of PDE4, but Not PDE3, Increase ß2-agonist-induced Expression of Anti-inflammatory MKP-1 in Airway Smooth Muscle Cells. Am J Respir Cell Mol Biol 2014; ISN1535-4989; DOI: 10.1165.  Back to cited text no. 4
Abbott-Banner KH, Page CP. Dual PDE3/4 and PDE4 inhibitors: Novel treatments for COPD and other inflammatory airway diseases. Basic Clin Pharmacol Toxicol 2014;114:365-76.  Back to cited text no. 5