Advanced Biomedical Research
Blood transfusion safety: A study of adverse reactions at the blood bank of a tertiary care center
Authors
Department of Pathology, Himalayan Institute of Medical Sciences, Dehradun, Uttarakhand, India
Abstract
Background: An adverse transfusion reaction (ATR) is an unfavorable reaction to the transfused unit, the severity of which may be different among individuals depending upon the type of reaction and the patient's susceptibility. Transfusion reactions may be immediate or delayed type depending on the onset and immune or nonimmune type depending on the pathogenesis. A study was conducted to study the frequency of various transfusion reactions and the associated morbidity.
Materials and Methods: All ATRs occurring over a period of 3 years at a tertiary care health center were studied in detail according to the institute's protocol.
Results: Of 38,013 units of blood and components that had been issued, 101 (0.2%) cases had an ATR. The most common reaction was allergic - 34/101 (33.6%) followed by febrile - 26/101 (25.7%). Other reactions included transfusion-related acute lung injury in 6/101 (5.9%) cases, and immune reactions were seen in 19/101 (18.8%) cases.
Conclusion: Allergic and febrile reactions are most common and least harmful, but fatal reactions can also occur, and preventive measures must be taken to avoid such reactions.
Keywords
| 1. |
Arewa OP, Akinola NO, Salawu L. Blood transfusion reactions; evaluation of 462 transfusions at a tertiary hospital in Nigeria. Afr J Med Med Sci 2009;38:143-8.  |
| 2. |
Williamson LM, Lowe S, Love EM, Cohen H, Soldan K, McClelland DB, et al. Serious hazards of transfusion (SHOT) initiative: Analysis of thefirst two annual reports. BMJ 1999;319:16-9. |
| 3. |
Harmening DM. Modern Blood Banking and Transfusion Practices. 3rd ed. Philadelphia: FA Davis Company; 1998. |
| 4. |
Geiger TL, Howard SC. Acetaminophen and diphenhydramine premedication for allergic and febrile nonhemolytic transfusion reactions: Good prophylaxis or bad practice? Transfus Med Rev 2007;21:1-12. |
| 5. |
Sovic D, Dodig J, Banovic M, Jularic A. Transfusion treatment at Sestre Milosrdnice university hospital center during a twelve-year period. Acta Clin Croat 2014;53:342-7. |
| 6. |
Bhattacharya P, Marwaha N, Dhawan HK, Roy P, Sharma RR. Transfusion-related adverse events at the tertiary care center in North India: An institutional hemovigilance effort. Asian J Transfus Sci 2011;5:164-70. [PUBMED] 
|
| 7. |
Jadhav MV, Kurade N, Sahasrabudhe N, Bapat VM. Blood transfusion associated fatalities. Indian J Med Sci 2000;54:330-4. [PUBMED]
|
| 8. |
Hirayama F. Recent advances in laboratory assays for nonhemolytic transfusion reactions. Transfusion 2010;50:252-63. |
| 9. |
Kahar MA, Shah R. Adverse transfusion reactions: Recognition, management and prevention. Pathol Lab Med 2015;7:97-107. |
| 10. |
Narvios AB, Lichtiger B, Neumann JL. Underreporting of minor transfusion reactions in cancer patients. Med Gen Med 2004;6:17. |
| 11. |
Harvey AR, Basavaraju SV, Chung KW, Kuehnert MJ. Transfusion-related adverse reactions reported to the National Healthcare Safety Network Hemovigilance Module, United States, 2010 to 2012. Transfusion 2014;55:707-18. |
| 12. |
Kumar P, Thapliyal R, Coshic P, Chatterjee K. Retrospective evaluation of adverse transfusion reactions following blood product transfusion from a tertiary care hospital: A preliminary step towards hemovigilance. Asian J Transfus Sci 2013;7:109-15. [PUBMED]
|
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