Isolated pulmonary candidiasis in a patient with diabetes mellitus: A rare case report


1 Infectious Diseases and Tropical Medicine Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

2 Nosocomial Infection Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

3 Department of Hematology, Isfahan University of Medical Sciences, Isfahan, Iran


Fungal infections are as a cause of morbidity and mortality in immunocompromise patients. Because the respiratory tract is colonized with Candida, the presence of this agent in respiratory specimens makes the diagnosis of Candida pneumonia problematic. Candida pneumonia is a rare infection, and the majority of cases are secondary to hematogenous dissemination. Furthermore isolated Candida pneumonia originating from endotracheal inoculation is an extremely rare entity. We describe a case of isolated pulmonary candidiasis in the form multiple nodular lesions in a patient with long-term history of diabetes mellitus without evidence of fungemia or systemic involvement who responded to antifungal therapy.


Manolakaki D, Velmahos G, Kourkoumpetis T, Chang Y, Alam HB, De Moya MM, et al. Candida infection and colonization among trauma patients. Virulence 2010;1:367-75.  Back to cited text no. 1
Nobile CJ, Johnson AD. Candida albicans biofilms and human disease. Annu Rev Microbiol 2015;69:71-92.  Back to cited text no. 2
Shweihat Y, Perry J III, Shah D. Isolated Candida infection of the lung. Respir Med Case Rep 2015;16:18-19.  Back to cited text no. 3
Edwards JE Jr. Candida species. Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases. 8th ed. Philadelphia: Churchill Livingstone; 2015. p. 2879-94.  Back to cited text no. 4
Casqueiro J, Casqueiro J, Alves C. Infections in patients with diabetes mellitus: A review of pathogenesis. Indian J Endocrinol Metab 2012; 16 Suppl 1:S27-36.  Back to cited text no. 5
Knox KS, Meinke L. Role of bronchoalveolar lavage diagnostics in fungal infections. Clin Chest Med 2009;30:355-65.  Back to cited text no. 6
Yapar N. Epidemiology and risk factors for invasive candidiasis. Ther Clin Risk Manag 2014;10:95-105.  Back to cited text no. 7
Leroy O, Gangneux JP, Montravers P, Mira JP, Gouin F, Sollet JP, et al. Epidemiology, management, and risk factors for death of invasive Candida infections in critical care: A multicenter, prospective, observational study in France (2005-2006). Crit Care Med 2009;37:1612-8.  Back to cited text no. 8
Aly FZ, Blackwell CC, Mackenzie DA, Weir DM, Clarke BF. Factors influencing oral carriage of yeasts among individuals with diabetes mellitus. Epidemiol Infect 1992;109:507-18.  Back to cited text no. 9
Yasuda Y, Tobino K, Asaji M, Yamaji Y, Tsuruno K. Invasive candidiasis presenting multiple pulmonary cavitary lesions on chest computed tomography. Multidiscip Respir Med 2015;10:11.  Back to cited text no. 10