Advanced Biomedical Research

Leptin and its cardiovascular effects: Focus on angiogenesis

Reviewers

Authors

1 Department of Physiology and Pharmacology, Birjand University of Medical Sciences, Birjand, Iran

2 Department of Physiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Abstract

Leptin is an endocrine hormone synthesized by adipocytes. It plays a key role in the energy homeostasis in central and peripheral tissues and has additional roles are attributed to it, such as the regulation of reproduction, immune function, bone homeostasis, and angiogenesis. The plasma concentration of leptin significantly increases in obese individuals. In the present review, we give an introduction concerning leptin, its receptors, signaling pathways, and its effect on cardiovascular system, especially on angiogenesis.

Keywords

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Advanced Biomedical Research
Volume 1900, january
January 1923
Pages 1-7