Comparison of Nasal Mucociliary Function before and after Septorhinoplasty Surgery Using Saccharin Test

Document Type : Original Article

Authors
Mostafa Hashemi
Ali Reza Dadgostar
Nezamoddin Berjis
Department of Otolaryngology, Isfahan University of Medical Sciences, Isfahan, Iran
Abstract
Background: This study was carried out to compare mucociliary function (MCF) of nasal cavity before and after septorhinoplasty surgery by saccharin test. Materials and Methods: This study was carried out on 70 patients who needed septorhinoplasty surgery in Kashani and Alzahra Hospital during 2013–2014 to measure MCF. Saccharin test was performed on the patients before surgery and on three more intervals 1 day, 1 week, and on month after ward and the readings were recorded. Saccharin test is performed by placing saccharin granules on the anterior part of inferior turbinate and the time the patient feels the sweet taste is recorded the normal range is below 30 min. Results: Mean of test for each time interval was obtained and comparison of measurements was made reading were mean of saccharin test before surgery (7.74 ± 1.65 min) the day after surgery (7.75 ± 1.7 min), on week after surgery (15.04 ± 3.4), and 1 month after surgery (8.49 ± 2.08 min). The readings before surgery did not have statistically significant difference with the readings 1 day after surgery P = 0.99, but comparison of test results at other time intervals were significant (P < 0.001). A relative increase in saccharin test time was seen in a period of 1 month after surgery the rise was more noticeable in the 1st week compared to 1 month after surgery. Conclusion: This study in the period after septorhinoplasty surgery MCF undergoes slight impairment that gradually progresses to normal values during 1 month after surgery.

Keywords

1.
Flint PW, Haughey BH, Robbins KT, Thomas JR, Niparko JK, Lund VJ, et al. Cummings Otolaryngology: Head and Neck Surgery. 5th ed. USA maryland: Mosby, Elsevier; 2010. p. 661, 663, 745.  Back to cited text no. 1
    
2.
Levine H, Clemente MP. Sinus surgery: Endoscopic and Microscopic Approaches. Germany Stuttgart: Thieme; 2005. p. 76-9.  Back to cited text no. 2
    
3.
Youngs R, Wigand ME. Endoscopic surgery of the paranasal sinuses and anterior skull base. The Journal of Laryngology and Otology. 2009;123:148.  Back to cited text no. 3
    
4.
Scadding GK. Investigative Rhinology. London: Taylor & Francis; 2004. p. 50, 52.  Back to cited text no. 4
    
5.
Stanley P, MacWilliam L, Greenstone M, Mackay I, Cole P. Efficacy of a saccharin test for screening to detect abnormal mucociliary clearance. Br J Dis Chest 1984;78:62-5.  Back to cited text no. 5
    
6.
Stanley PJ, Wilson R, Greenstone MA, Mackay IS, Cole PJ. Abnormal nasal mucociliary clearance in patients with rhinitis and its relationship to concomitant chest disease. Br J Dis Chest 1985;79:77-82.  Back to cited text no. 6
    
7.
Rosenstein BJ. Diagnostic methods. In Cystic Fibrosis: Hobson ME, Geddes DM, editors. ? Johns Hopkins University School of Medicine, Baltimore, Maryland: Arnold; 2000.  Back to cited text no. 7
    
8.
Greenstone M, Cole PJ. Primary ciliary dyskinesia. Arch Dis Child 1984;59:704-6.  Back to cited text no. 8
    
9.
Kharitonov S, Alving K, Barnes PJ. Exhaled and nasal nitric oxide measurements: Recommendations. The European Respiratory Society Task Force. Eur Respir J 1997;10:1683-93.  Back to cited text no. 9
    
10.
Lundberg JO, Palm J, Alving K. Nitric oxide but not carbon monoxide is continuously released in the human nasal airways. Eur Respir J 2002;20:100-3.  Back to cited text no. 10
    
11.
Törnberg DC, Marteus H, Schedin U, Alving K, Lundberg JO, Weitzberg E. Nasal and oral contribution to inhaled and exhaled nitric oxide: A study in tracheotomized patients. Eur Respir J 2002;19:859-64.  Back to cited text no. 11
    
12.
Niedzielska IA, Wróbel K, Wziatek W, Bazarnik Z, Drugacz J. Mucociliary clearance and sense of smell following management of Le Fort maxilla fractures. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2006;102:287-91.  Back to cited text no. 12
    
13.
Janic T, Niedzielska I. Mucociliary clearance impairment after zygomaticomaxillary-orbital fractures. Oral Surg Oral Med Oral Pathol Oral Radiol 2013;115:e6-12.  Back to cited text no. 13
    
14.
Danielle M. Goto, Furosemide impairs nasal mucociliary clearance in humans, Respiratory Physiology & Neurobiology 170 (2010);246-52  Back to cited text no. 14
Advanced Biomedical Research
Volume 2017, December
December 2017
Pages 1-5