Advanced Biomedical Research
Comparison of Preoperative Infusion of Magnesium Sulfate and Mannitol on Intraocular Pressure Changes in Patients Undergoing Phacoemulsification Surgery
Document Type : Original Article
Authors
1 Department of Anesthesiology, Anesthesiology and Critical Care Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
2 Department of Anesthesiology, Medical School of Isfahan University of Medical Sciences, Isfahan, Iran
Abstract
Background: The present study has been designed to compare the effect of magnesium sulfate with mannitol on reducing intraocular pressure (IOP). Materials and Methods: During the phacoemulsification surgery, 105 patients randomly divided into three groups receiving 20% mannitol at a dose of 0.3 g/kg, 50% magnesium sulfate at a dose of 20 mg/kg, and placebo (normal saline), with the same volume (100 ml) and infusion time (10 min), were used for the first, second, and third groups, respectively. The IOP was measured before and immediately after the injection and 5 min after the end of the surgery and compared between the groups. Results: The mean IOP immediately after the injection had a significant difference in three groups (mannitol: 15.2 ± 2.5, magnesium sulfate: 14.7 ± 1.9, and normal saline: 13.8 ± 2.8; P = 0.044), and the IOP had a significant difference between normal saline and mannitol groups (0.027) while there was no significant difference between mannitol and magnesium sulfate groups (P = 0.34) and also between magnesium sulfate and normal saline groups (P = 0.2). Conclusion: Using magnesium sulfate had no effect on changes in the IOP and hemodynamic of patients during the surgery. Using mannitol may be effective in reducing IOP while no effect of magnesium sulfate on IOP was found.
Keywords
| 1. |
Sunita A, Athiya A, Amar A. Phacoemulsification. 3rd ed. New Delhi: Medical Publishers (P) LTD; 2004. p. 4, 5, 6, 7, 296, 297.  |
| 2. |
Eriksson LI, Fleiser L, Wiener-Kronish JP, Young WL. Miller's Anesthesia. 7th ed. Printed in the United States of America: Publishing Services Manager, Tina Rebane; 2009. p. 98, 99, 100, 101, 102. |
| 3. |
Rand Allingham R, Damji KF, Freedman S, Moroi SE, Rhee DJ. Shilds Text Book of Glaucoma. 6th ed. Philadelphia, PA, USA: Lippincott Williams & Wilkins; 2011. p. 394, 395. |
| 4. |
Širvinskas E, Laurinaitis R. Use of magnesium sulfate in anesthesiology. Medicina (Kaunas). 2002;38:695-8. |
| 5. |
McEvoy GK, editor. AHFS drug information, 2000. American Society of Health-System Pharmacists; 2000. |
| 6. |
Sorkhabi R, Khatibian P. Comparison of the accuracy of intraocular pressure measurement with three tonometer; Pulsair easy eye, Tonopen and Goldmann. Sci J Hamadan Univ Med Sci Health Serv 2010;16:20-5. |
| 7. |
Alishiri AA, Naderi M, Jadidi KH, Nourian V, Bolouki Moghaddam Y. Comparing the effect of laryngeal mask airway and endotracheal tube insertion on intraocular pressure. J Mazandaran Univ Med Sci 2010;20:47-51. |
| 8. |
Rezaee S, Amiri A, Deilami N, Araghi S, Abadi MD. The effect of Cataract Surgery on Intraocular Pressure Change: Extracapsular Cataract Extraction vs. Phacoemulsification. Journal of Mazandaran University of Medical Sciences. 2012;21:152-7. |
| 9. |
Kashi AH, Fotouhil A, Hashemi H, Mohammadl K. Intraocular Pressure And Its Determinants In Tehran Population. Tehran University Medical Journal TUMS Publications. 2005;63:228-39. |
| 10. |
Alipanahi R, Lotfi N. Traumatic hyphema management and Mannitol role in young patients below 20 years. Children. 2000;37:338-43. |
| 11. |
Heshmati F, Zeinali MB, Sharifi N, Abbasivash R, Mahoori AR, Rafati M. Comparative study of the effect of intravenous Midazolam premedication on the intraocular pressure in intraocular surgeries. J Iran Soc Anaesthesiol Intensive Care 2004;24:17-22. |
| 12. |
Ghaffaripour S, Mahmoudi H, Eghbal H, Rahimi A. The effect of intravenous magnesium sulfate on post-operative analgesia during laminectomy. Cureus. 2016;8:e626.
|
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