Minocycline may be useful to prevent or treat methamphetamine-induced neural cell death: Hypothetic role of autophagia and apoptosis signaling pathway



1 Razi Drug Research Center, Iran University of Medical Sciences, Tehran, Tabriz, Iran

2 Division of Cognitive Neuroscience, University of Tabriz, Tabriz, Iran

Rahimi Borumand M, Motaghinejad M, Motevalian M, Gholami M. Duloxetine by modulating the Akt/GSK3 signaling pathways has neuroprotective effects against methamphetamine-induced neurodegeneration and cognition impairment in rats. Iran J Med Sci 2019; 44:146-54.  Back to cited text no. 1
Casaletto KB, Obermeit L, Morgan EE, Weber E, Franklin DR, Grant I, et al. Depression and executive dysfunction contribute to a metamemory deficit among individuals with methamphetamine use disorders. Addict Behav 2015; 40:45-50.  Back to cited text no. 2
Olmos G, Lladó J. Tumor necrosis factor alpha: A link between neuroinflammation and excitotoxicity. Mediators Inflamm 2014;2014: 861231  Back to cited text no. 3
Poon HF, Abdullah L, Mullan MA, Mullan MJ, Crawford FC. Cocaine-induced oxidative stress precedes cell death in human neuronal progenitor cells. Neurochem Int 2007; 50:69-73.  Back to cited text no. 4
Elkashef A, Vocci F, Hanson G, White J, Wickes W, Tiihonen J. Pharmacotherapy of methamphetamine addiction: An update. Subst Abus 2008; 29:31-49.  Back to cited text no. 5
Ballester J, Valentine G, Sofuoglu M. Pharmacological treatments for methamphetamine addiction: Current status and future directions. Expert Rev Clin Pharmacol 2017; 10:305-14.  Back to cited text no. 6
Miao H, Li R, Han C, Lu X, Zhang H. Minocycline promotes posthemorrhagic neurogenesis via M2 microglia polarization via upregulation of the TrkB/BDNF pathway in rats. J Neurophysiol 2018; 120:1307-17.  Back to cited text no. 7
Scott G, Zetterberg H, Jolly A, Cole JH, De Simoni S, Jenkins PO, et al. Minocycline reduces chronic microglial activation after brain trauma but increases neurodegeneration. Brain 2018; 141:459-71.  Back to cited text no. 8
Stirling DP, Koochesfahani KM, Steeves JD, Tetzlaff W. Minocycline as a neuroprotective agent. Neuroscientist 2005; 11:308-22.  Back to cited text no. 9
Lee SM, Yune TY, Kim SJ, Kim YC, Oh YJ, Markelonis GJ, et al. Minocycline inhibits apoptotic cell death via attenuation of TNF-alpha expression following iNOS/NO induction by lipopolysaccharide in neuron/glia co-cultures. J Neurochem 2004; 91:568-78.  Back to cited text no. 10