Prevalence of Helicobacter pylori infection among type 2 diabetes mellitus

Authors
Abdulbari Bener 1
Ahmet Faruk Ağan 2
Abdulla O. A A. Al-hamaq 3
Cem Cahit Barisik 4
Mustafa Öztürk 5
Abdulkadir Ömer 5
1 Department of Biostatistics and Medical Informatics, Cerrahpaşa Faculty of Medicine, Istanbul University, Istanbul, Turkey; Department of Evidence for Population Health Unit, Department of Epidemiology and Health Sciences, The University of Manchester, Manchester, UK; Department of Raiology and Pathology, Medipol International School of Medicine, Istanbul Medipol University, Istanbul, Turkey
2 Department of Gastroenterology, Medipol International School of Medicine, Istanbul Medipol University, Istanbul, Turkey
3 Qatar Diabetic Associations and Qatar Foundation, Doha, Qatar
4 Department of Raiology and Pathology, Medipol International School of Medicine, Istanbul Medipol University, Istanbul, Turkey
5 Department of Endocrinology, Medipol International School of Medicine, Istanbul Medipol University, Istanbul, Turkey
Abstract
Background: Several conducted studies have reported a higher and more frequent Helicobacter pylori infection rate in type 2 diabetes mellitus (T2DM). The aim of this study was to investigate the prevalence and its association between H. pylori infection and T2DM. Materials and Methods: A case and control study was conducted based on 529 T2DM patients and 529 control. H. pylori was assessed by Serum anti-H. pylori immunoglobulin G (IgG) and IgA. Furthermore, patients were investigated for fasting blood glucose (FBG) levels, glycosylated hemoglobin (HbA1c), serum cholesterol, and other biochemistry parameters. Results: The findings showed a positive significantly higher antibody titer for H. pylori infection (IgA > 250) in diabetic patients (50.7%) compared to controls (38.2%) (P < 0.001). Similarly, H. pylori infection for IgG > 300 titer was higher in T2DM patients (73.5%) compared to controls 61.8%) (P < 0.001). Further, the mean values were statistically significant diabetes with H. pylori infection for IgG > 300 titer and IgA > 250 titer, regarding Vitamin D, HbA1C (P < 0.001), FBG, calcium, creatinine, total cholesterol, LHDL, triglyceride levels, uric acid, bilirubin, thyroid-stimulating hormone (TSH), and systolic and diastolic blood pressure. The diabetic patients showed higher prevalence rate of symptoms than controls included: hypertension (14.3%), vomiting (15.5%), muscular symptoms (35.2%), bloating/distension (13.2%), abdominal pain (17%), nausea (9.6%), anemia (17%), kidneys (20.8%), chronic bronchitis (14.7%), gastrointestinal (23.8%), and diarrhea (20.4%). Conclusions: The current study revealed that H. pylori infections were significantly higher in diabetic patients compared to controls. Furthermore, T2DM patients infected with H. pylori positive reported a higher prevalence rate of symptoms than H. pylori negative.

Keywords

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Advanced Biomedical Research
Volume 2020, july
July 2020
Pages 1-6