Effectiveness of ozone injection therapy in temporomandibular disorders



Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran


Temporomandibular disorder is a multifactorial disease that causes pain in the jaw and face area with nondental origin, which frequently limits talking, chewing, and other jaw activities. Various factors such as malocclusion, trauma, stress, parafunctional habits (clenching and bruxing), osteoarthritis, and synovitis play a role in its occurrence, although the etiology of these disorders is little understood. Several treatments are being used to treat these disorders. Ozone therapy has been recently introduced as one of these treatments. Considering that no extensive study has been found in this field so far, this study is aiming to report the studies that have been conducted to determine the efficacy of ozone injection therapy in temporomandibular joint disorders. This report addresses the studies which are conducted clinically, experimentally, and semi-experimentally over the past 10 years (2009–2019). The prepared articles are screened according to the inclusion criteria. In this study, total six related articles are addressed. One study was pre- and postintervention, and five studies were clinical trials. Studies show that although more studies are needed in contrast with occlusal splint, ozone therapy is generally more effective treatment for pain reduction compared to medication.


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Doǧan M, Ozdemir Doǧan D, Düger C, Ozdemir Kol I, Akpınar A, Mutaf B, et al. Effects of high-frequency bio-oxidative ozone therapy in temporomandibular disorder-related pain. Med Princ Pract 2014;23:507-10.  Back to cited text no. 18
Celakil T, Muric A, Gökcen Roehlig B, Evlioglu G. Management of pain in TMD patients: Bio-oxidative ozone therapy versus occlusal splints. Cranio 2019;37:85-93.  Back to cited text no. 19
Özalp Ö, Yildırımyan N, Sindel A, Ali AM, Şükrü KR. Evaluation of the short-term efficacy of transdermal ozone therapy in Turkish patients with internal derangement of the temporomandibular joint. Pesqui Bras Odontopediatria Clín Integr 2019;19:4442.  Back to cited text no. 20
Reyes JM, Alghannam DJ. Ozone therapy as an alternative treatment to the pain in the temporomandibular disorder. Int Conf Pain Res Manag 2016;5 Suppl 5:61.  Back to cited text no. 21
Daif ET. Role of intra-articular ozone gas injection in the management of internal derangement of the temporomandibular joint. Oral Surg Oral Med Oral Pathol Oral Radiol 2012;113:e10-4.  Back to cited text no. 22
Hammuda A, Hamed MS, El-Sharrawy EA, Elsholkamy MA, Iskandar A. Use of ozone in temporomandibular joint arthrocentesis, clinical study. J Am Sci 2013;9:508-13.  Back to cited text no. 23
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Srivastava R, Jyoti B, Devi P. Oral splint for temporomandibular joint disorders with revolutionary fluid system. Dent Res J (Isfahan) 2013;10:307-13.  Back to cited text no. 25
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