The effect of Sargassum glaucescens from the Persian gulf on neuropathy pain induced by paclitaxel in mice


1 Department of Pharmacognosy, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran

2 Department of Pharmacognosy, School of Pharmacy and Pharmaceutical Sciences, Student Research Committee, Isfahan University of Medical Sciences, Isfahan, Iran

3 Applied Physiology Research Center, Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran


Background: Marine seaweeds are a famous type of traditional food containing various kinds of secondary metabolites. These organisms have different biological activities such as antitumor, antiviral, and antioxidant. The aim of this study was to investigate the effects of total extract of Sargassum glaucescens on neuropathy pain induced by paclitaxel in mice. Materials and Methods: S. glaucescens was collected from the Persian Gulf. The seaweed was extracted by maceration with methanol-ethyl acetate (1:1) solvent. The effect of the extract on neuropathy pain induced by paclitaxel was analyzed. All results were analyzed by one-way analysis of variance. Results: Acute administration of S. glaucescens extract (100 and 200 mg/kg intraperitoneally [i.p.]) 30 min before the test on the 11th day significantly reduced the duration of paw licking (P < 0.001). Conclusions: Chronic treatment with S. glaucescens extract (100, 150, and 200 mg/kg i.p.) from the 6th day until the 10th day reduced the duration of paw licking. Therefore, S. glaucescens should be considered for further treatment of neuropathy.


S, Wild, C P. Wild, editors. World Cancer Report 2014. In: International Agency for Research on Cancer. France: WHO Press, IARC Publisher; 2014.  Back to cited text no. 1
Rivera E, Cianfrocca M. Overview of neuropathy associated with taxanes for the treatment of metastatic breast cancer. Cancer Chemother Pharmacol 2015;75:659-70.  Back to cited text no. 2
Scripture CD, Figg WD, Sparreboom A. Peripheral neuropathy induced by paclitaxel: Recent insights and future perspectives. Curr Neuropharmacol 2006;4:165-72.  Back to cited text no. 3
Postma, TJ, Vermorken JB, Liefting AJ, Pinedo HM, Heimnas JJ. Paclitaxel-induced neuropathy. Ann Oncol 1995;6:489-94.  Back to cited text no. 4
Ghannadi A, Shabani L, Yegdaneh A. Cytotoxic, antioxidant and phytochemical analysis of Gracilaria species from Persian Gulf. Adv Biomed Res 2016;5:139.  Back to cited text no. 5
Woolf CJ, Mannion RJ. Neuropathy pain: Aetiology, symptoms, mechanisms, and management. Lancet 1999;353:1959-64.  Back to cited text no. 6
Jensen TS, Gottrup H, Sindrup SH, Bach FW. The clinical picture of neuropathy pain. Eur J Pharmacol 2001;429:1-11.  Back to cited text no. 7
Hoang SN, Dinch KC, Hoang MH, Dang DH. Initial Study of Screening of Anti-Inflammatory Compounds from Some Species of Vietnamese Seaweeds. Proceeding of National Conference on Life Sciences. Quy Nhon City: Quy Nhon University, Science and Technics Publishing House; 2007. p. 773-6.  Back to cited text no. 8
Esfahani HN, Vaseghi G, Safaiean L, Pilehvaran A, Abed A, Rfiiean M. Gender differences in a mouse model of chemotherapy-induced neuropathy pain. Lab Anim 2016;50:15-20.  Back to cited text no. 9
Kang JY, Khan MN, Park NH, Cho JY, Lee MC, Fujii H, et al. Antipyretic, analgesic, and anti-inflammatory activities of the seaweed Sargassum fulvellum and Sargassum thunbergii in mice. J Ethnopharmacol 2008;116:187-90.  Back to cited text no. 10
Itoh H, Noda H, Amano H, Zhuaug C, Mizuno T, Ito H. Antitumor activity and immunological properties of marine algal polysaccharides, especially fucoidan, prepared from Sargassum thunbergii of Phaeophyceae. Anticancer Res 1993;13:2045-52.  Back to cited text no. 11
Cho SH, Kang SE, Cho JY, Kim AR, Park SM, Hong YK, et al. The antioxidant properties of brown seaweed (Sargassum siliquastrum) extracts. J Med Food 2007;10:479-85.  Back to cited text no. 12
Ghannadi A, Plubrukarn A, Zandi K, Sartavi K, Yegdaneh A. Screening for antimalarial and acetylcholinesterase inhibitory activities of some Iranian seaweeds. Res Pharm Sci 2013;8:113-8.  Back to cited text no. 13
Sohrabipour J, Rabiei R, The Checklist of Green Algae of the Iranian Coastal Lines of the Persian Gulf and Gulf of Oman; Iran. J. Bot. 2007;13:146-9.  Back to cited text no. 14
Mori T, Kanbara T, Harumiya M, Iwase Y, Masumoto A, Komiya S, et al. Establishment of opioid-induced rewarding effects under oxaliplatin- and paclitaxel-induced neuropathy in rats. J Pharmacol Sci 2014;126:47-55.  Back to cited text no. 15
Vaseghi G, Sharifi M, Dana N, Ghasemi A, Yegdaneh A. Cytotoxicity of sargassum angustifolium partitions against breast and cervical cancer cell lines. Adv Biomed Res 2018;7:43.  Back to cited text no. 16
Akbari V, Zafari S, Yegdaneh A. Anti-tuberculosis and cytotoxic evaluation of the seaweed Sargassum boveanum. Res Pharm Sci 2018;13:30-7.  Back to cited text no. 17
Yegdaneh A, Putchakarn S, Yuenyongsawad S, Ghannadi A, Plubrukarn A. 3-oxoabolene and 1-oxocurcuphenol, aromatic bisabolanes from the sponge Myrmekioderma sp. Nat Prod Commun 2013;8:1355-7.  Back to cited text no. 18
Mehdinezhad N, Ghannadi A, Yegdaneh A. Phytochemical and biological evaluation of some Sargassum species from Persian Gulf. Res Pharm Sci 2016;11:243-9.  Back to cited text no. 19
Gu W, Chen J, Patra P, Yang X, Gu Q, Wei L, et al. Nanoformulated water-soluble paclitaxel to enhance drug efficacy and reduce hemolysis side effect. J Biomater Appl 2017;32:66-73.  Back to cited text no. 20
Yang PP, Yeh GC, Huang EY, Law PY, Loh HH, Tao PL. Effects of dextromethorphan and oxycodone on treatment of neuropathy pain in mice. J Biomed Sci 2015;22:81.  Back to cited text no. 21
Hong DD, Hien HM, Anh HT. Studies on the analgesic and anti-inflammatory activities of Sargassum swartzii (Turner) C. Agardh (Phaeophyta) and Ulva reticulata Forsskal (Chlorophyta) in experiment animal models. Afr J Biotechnol 2011;10:2308-13.  Back to cited text no. 22