Advanced Biomedical Research

Evaluation of diagnostic accuracy of alpha-fodrin antibody in Iranian patients with Sjogren's disease

Document Type : Original Article

Authors

1 Student Research Committee, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

2 Department of Pathology, Isfahan University of Medical Sciences, Isfahan, Iran

3 Department of Internal Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

4 Department of Digestive Diseases Research Institute, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran

Abstract

Background: Sjogren's syndrome, as a chronic autoimmune disease, involves in lymphocytic infiltration in the exocrine glands. As the result of exocrine glands disruption, the clinical hallmark of this disease including dryness of mouth and eyes along with fatigue and joint pain occur. However, heterogeneity of clinical presentations among newly diagnosed adult patients with Sjogren's syndrome leads to difficulty in its diagnosis. One of the diagnostic criteria for Sjogren's syndrome is the presence of autoantibodies in patient serum. One of the novel biomarkers suggested for diagnosis of Sjogren is alpha-fodrin antibody. In this study, we aimed to evaluate the diagnostic power of anti-α-fodrin antibody among the Iranian population for the first time. Materials and Methods: We recruited 82 individuals in this study. Alpha-fodrin were measured in case and control with Elisa kit as 16.71 (9.84) and 18.44 (11.54). Results: There was no any significant difference between two groups regarding alpha-fodrin level (P = 0.35). Then we applied the receiver operating characteristic (ROC) curve analysis to determine the predictive value of alpha-fodrin for diagnosing Sjogren's disease. The area under curve of the ROC curve was calculated as 0.5453. Also, there were significant association between age and alpha-fodrin antibody. Conclusions: Alpha-fodrin test did not have acceptable predictive power for predicting Sjogren's disease; however, it could be associated with disease progression.

Keywords

1.
Yu W, Qu W, Wang Z, Xin C, Jing R, Shang Y, et al. Sjogren's syndrome complicating pancytopenia, cerebral hemorrhage, and damage in nervous system: A case report and literature review. Medicine (Baltimore) 2017;96:e8542.  Back to cited text no. 1
    
2.
Qin B, Wang J, Yang Z, Yang M, Ma N, Huang F, et al. Epidemiology of primary Sjögren's syndrome: A systematic review and meta-analysis. Ann Rheum Dis 2015;74:1983-9.  Back to cited text no. 2
    
3.
Meijer JM, Meiners PM, Huddleston Slater JJ, Spijkervet FK, Kallenberg CG, Vissink A, et al. Health-related quality of life, employment and disability in patients with Sjögren's syndrome. Rheumatology 2009;48:1077-82.  Back to cited text no. 3
    
4.
Vivino FB. Sjogren's syndrome: Clinical aspects. Clin Immunol 2017;182:48-54.  Back to cited text no. 4
    
5.
Shiboski CH, Shiboski SC, Seror R, Criswell LA, Labetoulle M, Lietman TM, et al. 2016 American College of Rheumatology/European League Against Rheumatism classification criteria for primary Sjögren's syndrome: A consensus and data-driven methodology involving three international patient cohorts. Ann Rheum Dis 2017;76:9-16.  Back to cited text no. 5
    
6.
Mariette X, Criswell LA. Primary Sjögren's syndrome. N Engl J Med 2018;378:931-9.  Back to cited text no. 6
    
7.
Johr CR, Vivino FB. Biologic therapy in the treatment of Sjögren's syndrome: A clinical perspective. Curr Treatm Opt Rheumatol 2018;4:85-98.  Back to cited text no. 7
    
8.
Shiboski S, Shiboski C, Criswell L, Baer A, Challacombe S, Lanfranchi H, et al. American College of Rheumatology classification criteria for Sjögren's syndrome: A data-driven, expert consensus approach in the Sjögren's International Collaborative Clinical Alliance cohort. Arthritis Care Res 2012;64:475-87.  Back to cited text no. 8
    
9.
Kay J, Upchurch KS. ACR/EULAR 2010 rheumatoid arthritis classification criteria. Rheumatology (Oxford) 2012;51 Suppl 6:i5-9.  Back to cited text no. 9
    
10.
Brito-Zeron P, Baldini C, Bootsma H, Bowman SJ, Jonsson R, Mariette X, et al. Sjögren syndrome. Nat Rev Dis Primers 2016;2:1-20.  Back to cited text no. 10
    
11.
Haga HJ, Hulten B, Bolstad AI, Ulvestad E, Jonsson R. Reliability and sensitivity of diagnostic tests for primary Sjögren's syndrome. J Rheumatol 1999;26:604-8.  Back to cited text no. 11
    
12.
Garcic-Carrasco M, Font J, Filella X, Cervera R, Ramos-Casals M, Siso A, et al. Circulating levels of Th1/Th2 cytokines in patients with primary Sjögren's syndrome: Correlation with clinical and immunological features. Clin Exp Rheumatol 2001;19:411-5.  Back to cited text no. 12
    
13.
Bombardieri M, McInnes IB, Pitzalis C. Interleukin-18 as a potential therapeutic target in chronic autoimmune/inflammatory conditions. Expert Opin Biol Ther 2007;7:31-40.  Back to cited text no. 13
    
14.
Ciccia F, Guggino G, Rizzo A, Ferrante A, Raimondo S, Giardina A, et al. Potential involvement of IL-22 and IL-22-producing cells in the inflamed salivary glands of patients with Sjögren's syndrome. Ann Rheum Dis 2012;71:295-301.  Back to cited text no. 14
    
15.
Barone F, Nayar S, Campos J, Cloake T, Withers DR, Toellner KM, et al. IL-22 regulates lymphoid chemokine production and assembly of tertiary lymphoid organs. Proc Natl Acad Sci 2015;112:11024-9.  Back to cited text no. 15
    
16.
Sada PR, Isenberg D, Ciurtin C. Biologic treatment in Sjögren's syndrome. Rheumatology 2015;54:219-30.  Back to cited text no. 16
    
17.
Haneji N, Nakamura T, Takio K, Yanagi K, Higashiyama H, Saito I, et al. Identification of α-fodrin as a candidate autoantigen in primary Sjögren's syndrome. Science 1997;276:604-7.  Back to cited text no. 17
    
18.
Watanabe T, Tsuchida T, Kanda N, Mori K, Hayashi Y, Tamaki K. Anti–α-fodrin antibodies in Sjögren syndrome and lupus erythematosus. Arch Dermatol 1999;135:535-9.  Back to cited text no. 18
    
19.
Hu Q, Wang D, Chen W. The accuracy of the anti-α-fodrin antibody test for diagnosis of Sjögren's syndrome: A meta-analysis. Clin Biochem 2013;46:1372-6.  Back to cited text no. 19
    
20.
Bizzaro N, Villalta D, Tonutti E. Low sensitivity of anti-alpha-fodrin antibodies in patients with primary Sjögren's syndrome. J Rheumatol 2004;31:2310-1.  Back to cited text no. 20
    
21.
He J, Fang W, Li ZG. The application of combined detection of autoantibodies in primary Sjögren's syndrome. Zhonghua Nei Ke Za Zhi 2008;47:366-8.  Back to cited text no. 21
    
22.
Ruffatti A, Ostuni P, Grypiotis P, Botsios C, Tonello M, Grava C, et al. Sensitivity and specificity for primary Sjögren's syndrome of IgA and IgG anti-alpha-fodrin antibodies detected by ELISA. J Rheumatol 2004;31:504-7.  Back to cited text no. 22
    
Advanced Biomedical Research
Volume 2022, july
July 2022
Pages 1-5