Advanced Biomedical Research 2277-9175 2016 july 2016 07 01 The comparison between modified kligman formulation versus kligman formulation and intense pulsed light in the treatment of the post-burn hyperpigmentation 1 4 29308 EN Amir Hossein Siadat Department of Dermatology, Skin Diseases and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan, Iran 0000-0003-3201-7037 Fariba Iraji Department of Dermatology, Skin Diseases and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan, Iran Reza Bahrami Department of Pathology, Isfahan University of Medical Sciences, Isfahan, Iran Mohammad Ali Nilfroushzadeh Skin and Stem cell Research Center, Tehran University of Medical Sciences, Tehran, Iran Ali Asilian Department of Dermatology, Skin Diseases and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan, Iran Sheila Shariat Department of Pathology, Isfahan University of Medical Sciences, Isfahan, Iran Zahra Nikyar Department of Dermatology, Skin Diseases and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan, Iran Safura Bokaie Department of Pathology, Isfahan University of Medical Sciences, Isfahan, Iran Journal Article 2023 03 04 <strong>Background</strong>: Post inflammatory hyperpigmentation (PIH) is a common problem occurs following many dermatologic diseases and medical interventions. Different modalities including topical agents, lasers and intense pulsed light (IPL) are suggested for treatment of the post-burn PIH. In the current study, we evaluated the efficacy of IPL plus modified Kligman cream (MODIFIED KLIGMAN CREAM) versus MODIFIED KLIGMAN CREAM alone in the treatment of the post-burn PIH.<br /><strong>Materials and Methods</strong>: This was a randomized, non-blinded clinical trial. A total of 53 patches of post-burn PIP in 14 patients were randomized to receive either two sessions of IPL plus modified Kligman formula or kligman formula for 2 months. The patients were recommended to apply MODIFIED KLIGMAN CREAM cream for 12 h at night.<br /><strong>Results</strong>: According to our results, the patients in the MODIFIED KLIGMAN CREAM + IPL group had higher satisfaction as compared with MODIFIED KLIGMAN CREAM alone (<em>P</em> = 0.000) (Mann–Whitney test). In addition, according to physician evaluation, the patients in the MODIFIED KLIGMAN CREAM + IPL group had higher satisfaction as compared with MODIFIED KLIGMAN CREAM alone (<em>P</em> = 0.000) (Mann–Whitney test). No side effects except a little irritation, erythema and exfoliation due to MODIFIED KLIGMAN CREAM cream were seen in the patients.<br /><strong>Conclusions</strong>: The results of our study showed the better efficacy and faster response of the IPL plus modified Kligman formula versus modified Kligman formula in the treatment of the post-burn PIH. To better determine the efficacy of IPL in treatment of the post-burn PIP, more extensive studies as randomized, double-blinded clinical trial are recommended. https://advbiores.mui.ac.ir/article_29308_229b80a4b334bbda34ec0d063f11c699.pdf