Tangibility of platelet-rich fibrin matrix for nasolabial folds

Authors

1 Department of Plastic Surgery, Isfahan University of Medical Sciences, Isfahan, Iran

2 Department of General Surgery, Isfahan University of Medical Sciences, Isfahan, Iran

3 Department of Pathology, Isfahan University of Medical Sciences, Isfahan, Iran

Abstract

Background: Using autologous tissue is a simple process and ideal choice for augmentation of the soft facial tissue. In this regard, platelet-rich fibrin matrix (PRFM) is used for the correction of fine rhytids and nasolabial folds (NLFs) as well as facial augmentation. This study tries to evaluate the tangibility of PRFM for facial augmentation.
Materials and Methods: In this study, 20 patients (20–45 years) were studied to examine the augmentation (4 patients were excluded). For each, 3cc of PRFM provided by using 35cc of autologous blood and injected through subdermal technique into NLFs. Thickness and volume of the tissue were measured before and 3 months after treatment by sonography. The collected data were analyzed through paired t-test and independent t- test by using SPSS version 19.0 (SPSS Inc., Chicago, IL, USA).
Results: The study included 16 women, with average of 39.43 ± 6.84 years (age range, 20–45 years). The thickness and the volume of subcutaneous tissue in NLFs before and after treatment show no significant difference on the right side rather than on the left side (P > 0.05), but the thickness and the volume of the tissue on both sides after treatment shows significant increase rather than before treatment, so that this increase was significant statistically. This study shows that different right and left thickness was 0.54 ± 0.51 and 0.51 ± 0.38 (P ≤ 0.001). Further, different right and left volume was 0.25 ± 0.20 and 0.26 ± 0.22, respectively (P < 0.001).
Conclusion: According to the results, the increased tissue volume by PRFM still persists after 3 months of treatment and its retention has been effective on the healing process.

Keywords

1.
Sclafani AP, McCormick SA. Induction of dermal collagenesis, angiogenesis, and adipogenesis in human skin by injection of platelet-rich fibrin matrix. Arch Facial Plast Surg 2012;14:132-6.  Back to cited text no. 1
    
2.
Sclafani AP, Romo T 3rd, Parker A, McCormick SA, Cocker R, Jacono A. Autologous collagen dispersion (Autologen) as a dermal filler: Clinical observations and histologic findings. Arch Facial Plast Surg 2000;2:48-52.  Back to cited text no. 2
    
3.
Watson D, Keller GS, Lacombe V, Fodor PB, Rawnsley J, Lask GP. Autologous fibroblasts for treatment of facial rhytids and dermal depressions. A pilot study. Arch Facial Plast Surg 1999;1:165-70.  Back to cited text no. 3
    
4.
Roy S, Driggs J, Elgharably H, Biswas S, Findley M, Khanna S, et al. Platelet-rich fibrin matrix improves wound angiogenesis via inducing endothelial cell proliferation. Wound Repair Regen 2011;19:753-66.  Back to cited text no. 4
    
5.
Anitua E, Sanchez M, Nurden AT, Zalduendo M, de la Fuente M, Orive G, et al. Autologous fibrin matrices: A potential source of biological mediators that modulate tendon cell activities. J Biomed Mater Res A 2006;77:285-93.  Back to cited text no. 5
    
6.
Sclafani AP. Safety, efficacy, and utility of platelet-rich fibrin matrix in facial plastic surgery. Arch Facial Plast Surg 2011;13:247-51.  Back to cited text no. 6
    
7.
Bielecki T, Dohan Ehrenfest DM. Platelet-rich plasma (PRP) and Platelet-Rich Fibrin (PRF): Surgical adjuvants, preparations for in situ regenerative medicine and tools for tissue engineering. Curr Pharm Biotechnol 2012;13:1121-30.  Back to cited text no. 7
    
8.
Carroll RJ, Arnoczky SP, Graham S, O'Connell SM. Characterization of Autologous Growth Factors in Cascade Platelet-rich Fibrin Matrix (PRFM). Edison, NJ: Musculoskeletal Transplant Foundation; 2005.  Back to cited text no. 8
    
9.
Sclafani AP. Platelet rich fibrin matrix for improvement of deep nasolabial folds. Presented at: The Annual Meeting of the Triological Society. J Cosmet Dermatol 2009;9:66-71.  Back to cited text no. 9
    
10.
Sclafani AP, Romo T 3rd, Ukrainsky G, McCormick SA, Litner J, Kevy SV, et al. Modulation of wound response and soft tissue ingrowth in synthetic and allogeneic implants with platelet concentrate. Arch Facial Plast Surg 2005;7:163-9.  Back to cited text no. 10
    
11.
Azzena B, Mazzoleni F, Abatangelo G, Zavan B, Vindigni V. Autologous platelet-rich plasma as an adipocyte in vivo delivery system: Case report. Aesthetic Plast Surg 2008;32:155-8.  Back to cited text no. 11
    
12.
Cervelli V, Gentile P. Use of platelet gel in Romberg syndrome. Plast Reconstr Surg 2009;123:22e-3e.  Back to cited text no. 12
    
13.
Lucarelli E, Beretta R, Dozza B, Tazzari PL, O'Connel SM, Ricci F, et al. A recently developed bifacial platelet-rich fibrin matrix. Eur Cell Mater 2010;20:13-23.  Back to cited text no. 13
    
14.
Asadi M, Alamdari DH, Rahimi HR, Aliakbarian M, Jangjoo A, Abdollahi A, et al. Treatment of life-threatening wounds with a combination of allogenic platelet-rich plasma, fibrin glue and collagen matrix, and a literature review. Exp Ther Med 2014;8:423-9.  Back to cited text no. 14